860624-89-1

Basic information

• Product Name: 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER;Methyl 5-bromoindole-7-carboxylate;methyl 5-bromo-1H-indole-7-carboxylate;5-BroMo-1H-indol-7-carboxylic acid Methyl ester;1H-Indole-7-carboxylic acid, 5-bromo-, methyl ester;5-Bromo-1H-indole-7-carboxylic acid methyl ester
• CAS NO: 860624-89-1
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08
• Mol File: 860624-89-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 382.6 °C at 760 mmHg
• Flash Point: 185.2 °C
• Appearance: /
• Density: 1.629 g/cm³
• Vapor Pressure: 4.68E-06mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.46±0.30(Predicted)
• CAS DataBase Reference: 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER(860624-89-1)
• EPA Substance Registry System: 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER(860624-89-1)

Safety Data

• Hazardous Substances Data: 860624-89-1(Hazardous Substances Data)

Usage

General Description

5-Bromoindole-7-carboxylic acid methyl ester is a chemical compound that contains a 5-bromoindole core with a carboxylic acid methyl ester functional group attached at the 7-position. It is commonly used in the synthesis of various organic compounds and pharmaceuticals. This chemical is known for its potential use in the development of new drugs and has been studied for its various biological activities. Additionally, it is important to handle this chemical with caution as it may pose hazards to human health and the environment.

InChI:InChI=1/C10H8BrNO2/c1-14-10(13)8-5-7(11)4-6-2-3-12-9(6)8/h2-5,12H,1H3

Upstream product

• 1065181-58-9 ethyl 5-bromo-1H-indole-7-carboxylate 
• 1065181-56-7 ethyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 
• 1065181-52-3 1-(1,1-dimethylethyl) 7-ethyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 289039-83-4 methyl 2-amino-5-bromo-3-iodobenzoate 
• 1066-54-2 trimethylsilylacetylene 
• 860624-90-4 5-bromo-1H-indole-7-carboxylic acid 
• 74-88-4 methyl iodide 
• 197460-40-5 1-(1,1-dimethylethyl) 7-methyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 143262-10-6 1-(tert-butoxycarbonyl)indoline 
• 860624-87-9 1-(1,1-dimethylethyl) 7-methyl 5-bromo-2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 496-15-1 1-indoline 
• 875305-09-2 methyl 2-amino-5-bromo-3-((trimethylsilyl)ethynyl)benzoate 
• 860624-88-0 methyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 

Downstream Products

• 860624-91-5 5-bromo-1H-indole-7-carboxamide 
• 1065179-21-6 3-(1,1-dioxidotetrahydro-3-thienyl)-5-(4-fluorophenyl)-1H-indole-7-carboxamide 
• 1065182-25-3 3-(1,1-dioxido-4-thiepanyl)-5-phenyl-1H-indole-7-carboxylic acid 
• 1065179-27-2 3-(1,1-dioxidotetrahydrothiophen-3-yl)-5-phenyl-1H-indole-7-carboxamide 
• 1065177-35-6 5-[3-({[(1S)-1,2-dimethylpropyl]amino}methyl)phenyl]-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide 
• 1065177-11-8 5-[4-(cyanomethyl)phenyl]-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide 
• 1065177-33-4 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-{3-[(dimethylamino)methyl] phenyl}-1H-indole-7-carboxamide 
• 1065177-32-3 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-{3-[(methylamino)methyl] phenyl}-1H-indole-7-carboxamide 
• 1065184-15-7 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(3-formylphenyl)-1H-indole-7-carboxamide 

Relevant articles and documents

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so

CD38 INHIBITORS AND METHODS OF TREATMENT

Compounds of Formula (I) and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. Formula (I).

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.