860624-87-9

Basic information

• Product Name: 1H-Indole-1,7-dicarboxylic acid, 5-broMo-2,3-dihydro-, 1-(1,1-diMethylethyl) 7-Methyl ester
• Synonyms: 1H-Indole-1,7-dicarboxylic acid, 5-broMo-2,3-dihydro-, 1-(1,1-diMethylethyl) 7-Methyl ester;1-tert-Butyl 7-methyl 5-bromo-2,3-dihydro-1H-indole-1,7-dicarboxylate;5-Bromo-1-(tert-butoxycarbonyl)-2,3-dihydro-7-(methoxycarbonyl)-1H-indole, 5-Bromo-2,3-dihydro-7-(methoxycarbonyl)-1H-indole, N-BOC protected;Methyl 1-boc-5-broMoindoline-7-carboxylate;1-tert-Butyl 7-methyl 5-bromoindoline-1,7-dicarboxylate;methyl 1-N-Boc-5-bromo-2,3-dihydro-1H-indole-7-carboxylate
• CAS NO: 860624-87-9
• Molecular Formula: C₁₅H₁₈BrNO₄
• Molecular Weight: 357.21966
• Mol File: 860624-87-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 441.457 °C at 760 mmHg
• Flash Point: 220.786 °C
• Appearance: /
• Density: 1.42 g/cm³
• CAS DataBase Reference: 1H-Indole-1,7-dicarboxylic acid, 5-broMo-2,3-dihydro-, 1-(1,1-diMethylethyl) 7-Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1,7-dicarboxylic acid, 5-broMo-2,3-dihydro-, 1-(1,1-diMethylethyl) 7-Methyl ester(860624-87-9)
• EPA Substance Registry System: 1H-Indole-1,7-dicarboxylic acid, 5-broMo-2,3-dihydro-, 1-(1,1-diMethylethyl) 7-Methyl ester(860624-87-9)

Safety Data

• Hazardous Substances Data: 860624-87-9(Hazardous Substances Data)

Usage

Description

1H-Indole-1,7-dicarboxylic acid, 5-bromo-2,3-dihydro-, 1-(1,1-dimethylethyl) 7-methyl ester is a chemical compound with the molecular formula C17H20BrNO4. It is a derivative of 1H-indole-1,7-dicarboxylic acid and is commonly used as a building block in organic synthesis. 1H-Indole-1,7-dicarboxylic acid, 5-bromo-2,3-dihydro-, 1-(1,1-dimethylethyl) 7-methyl ester possesses a unique structure that includes a 5-bromo-2,3-dihydro-indole core, a 1,1-dimethylethyl group, and a methyl ester moiety at the 7-position. Its specific properties and potential uses make it an important compound in chemical research and development.

Uses

Used in Pharmaceutical Industry:
1H-Indole-1,7-dicarboxylic acid, 5-bromo-2,3-dihydro-, 1-(1,1-dimethylethyl) 7-methyl ester is used as a precursor in the synthesis of bioactive compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with potential activity against a range of diseases and conditions.
Used in Agrochemical Industry:
1H-Indole-1,7-dicarboxylic acid, 5-bromo-2,3-dihydro-, 1-(1,1-dimethylethyl) 7-methyl ester is used as a potential insecticide, leveraging its chemical properties to control or eliminate pests in agricultural settings. Its effectiveness in this application can contribute to increased crop yields and reduced reliance on harmful chemical pesticides.

Upstream product

• 496-15-1 1-indoline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 143262-10-6 1-(tert-butoxycarbonyl)indoline 
• 34619-03-9 tert-butyldicarbonate 
• 197460-40-5 1-(1,1-dimethylethyl) 7-methyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 

Downstream Products

• 860624-88-0 methyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 
• 860624-89-1 methyl 5-bromo-1H-indole-7-carboxylate 
• 860624-90-4 5-bromo-1H-indole-7-carboxylic acid 
• 860624-91-5 5-bromo-1H-indole-7-carboxamide 
• 1065179-21-6 3-(1,1-dioxidotetrahydro-3-thienyl)-5-(4-fluorophenyl)-1H-indole-7-carboxamide 
• 1065182-25-3 3-(1,1-dioxido-4-thiepanyl)-5-phenyl-1H-indole-7-carboxylic acid 
• 1090903-58-4 methyl 5-bromo-1,N-methylindole-7-carboxylate 
• 1065175-72-5 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide 
• 1065184-15-7 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(3-formylphenyl)-1H-indole-7-carboxamide 
• 1065177-32-3 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-{3-[(methylamino)methyl] phenyl}-1H-indole-7-carboxamide 
• 1065177-33-4 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-{3-[(dimethylamino)methyl] phenyl}-1H-indole-7-carboxamide 
• 1065177-11-8 5-[4-(cyanomethyl)phenyl]-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide 

Relevant articles and documents

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

The discovery and hit-to-lead exploration of a novel series of selective IKK-β kinase inhibitors is described. The initial lead fragment 3 was identified by pharmacophore-directed virtual screening. Homology model-driven SAR exploration of the template le

SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE

The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R2, R3, R10, E1, E2, E3, Y, and Z are as defined herein.

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.