106823-85-2Relevant academic research and scientific papers
Synthesis and?SAR study of?acridine, 2-methylquinoline and?2-phenylquinazoline analogues as?anti-prion agents
Cope,Mutter,Heal,Pascoe,Brown,Pratt,Chen
, p. 1124 - 1143 (2007/10/03)
Transmissible spongiform encephalopathies (TSEs) are thought to arise from aggregation of a protease resistant protein denoted PrPSc, which is a misfolded isoform of the normal cellular prion protein PrPC. Using virtual high-throughp
A New Synthesis of N-Substituted-2-alkyl(or aryl)quinazolin-4-amines by Amide Base-Mediated Cyclization of Carboximidamides Derived from 2-(Trifluoromethyl)benzenamine
Patterson, Steven E.,Janda, Lubomir,Strekowski, Lucjan
, p. 703 - 706 (2007/10/02)
A one-pot preparation carboximidamides (amidines) 11-14 involves treatment of amides 2-5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7-10 with ammonia.Amidines 11-14 are cyclized to quinazolines 20-26 i
