2946-71-6

Upstream product

• 393-11-3 4-nitro-3-(trifluoromethyl)benzeneamine 
• 98-88-4 benzoyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 93-98-1 N-phenyl benzoyl amide 
• 530-48-3 1,1-Diphenylethylene 
• 2926-29-6 Langlois reagent 
• 98-08-8 α,α,α-trifluorotoluene 
• 100-47-0 benzonitrile 
• 100-58-3 phenylmagnesium bromide 
• 2285-12-3 o-trifluoromethyl-phenylisocyanate 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 384-22-5 2-nitrobenzotrifluoride 

Downstream Products

• 64321-99-9 N-(2-Trifluoromethyl-phenyl)-benzimidoyl chloride 
• 106823-85-2 N,N-dimethyl-N’-(2-phenylquinazolin-4-yl)ethane-1,2-diamine 
• 143871-26-5 4-(4-methylpiperazin-1-yl)-2-phenylquinazoline 
• 143871-29-8 1-(iminophenylmethyl)-4-methylpiperazine 
• 143871-27-6 2-phenyl-4-(2,2,6,6-tetramethylpiperidin-1-yl)quinazoline 
• 145226-14-8 N'-<2-(trifluoromethyl)phenyl>benzenecarboximidamide 

Relevant academic research and scientific papers

Acetonitrile and benzonitrile as versatile amino sources in copper-catalyzed mild electrochemical C-H amidation reactions

A mild, efficient electrochemical approach to the site-selective direct C-H amidation of benzene and its derivatives with acetonitrile and benzonitrile has been developed. It has been shown that joint electrochemical oxidation of various arenes in the presence of a copper salt as a catalyst and nitriles leads to the formation of N-phenylacetamide from benzene and N-benzylacetamides from benzyl derivatives (up to 78% yield). A favorable feature of the process is mild conditions (room temperature, ambient pressure, no strong oxidants) that meet the criteria of green chemistry.

α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles

Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).

Visible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives

A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the "CF3" source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.

TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.

Experimental and computational insights into the nature of weak intermolecular interactions in trifluoromethyl-substituted isomeric crystalline N-methyl-N-phenylbenzamides

The knowledge about the prevalence of weak interactions in terms of the nature and energetics associated with their formation is of significance in organic solids. In the present study, we have systematically explored the existence of different types of i

Palladium-catalyzed trifluoromethylation of aromatic C-H bond directed by an acetamino group

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.

Role of intermolecular interactions involving organic fluorine in trifluoromethylated benzanilides

Trifluoromethylated benzanilides, containing C(sp3)-F bonds, have been synthesized and their crystal and molecular structures have been investigated to highlight the significance of weak intermolecular interactions associated with the presence

Quinoline-3-carboxamides

Novel quinoline-3-carboxamides of the formula STR1 wherein R1 is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, --CF3, --OCF3, --SCF3, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms and alkoxy of 1 to 4 carbon atoms, R2 is selected from the group consisting of hydrogen and methyl, R3 is selected from the group consisting of thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl and imidazolyl and R4 is selected from the group consisting of hydrogen, hydroxyl, alkyl of 1 to 4 carbon atoms, phenyl and benzyl with the proviso that when R1 is in the 7 or 8-position and is halogen, --CH3, --OCF3 or --SCF3 and R4 is hydrogen, R3 is not thiazolyl, pyridinyl or oxazolyl and the non-toxic, pharmaceutically acceptable acid addition salts when R3 is imidazolyl or 4,5-dihydrothiazolyl having analgesic activity and their preparation and novel intermediates therefore.