64321-99-9Relevant academic research and scientific papers
α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles
Burtoloso, Antonio C. B.,Caiuby, Clarice A. D.,De Jesus, Matheus P.
, p. 7433 - 7445 (2020/06/27)
Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).
A New Synthesis of N-Substituted-2-alkyl(or aryl)quinazolin-4-amines by Amide Base-Mediated Cyclization of Carboximidamides Derived from 2-(Trifluoromethyl)benzenamine
Patterson, Steven E.,Janda, Lubomir,Strekowski, Lucjan
, p. 703 - 706 (2007/10/02)
A one-pot preparation carboximidamides (amidines) 11-14 involves treatment of amides 2-5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7-10 with ammonia.Amidines 11-14 are cyclized to quinazolines 20-26 i
