106825-81-4Relevant articles and documents
NEW SYNTHESIS OF PIPECOLIC ACID AND ANALOGS
Asher, Vikram,Becu, Christian,Anteunis, Marc J. O.,Callens, Roland
, p. 141 - 144 (1981)
Pipecolic acid congeners are synthesised from α-cyanoamides, obtained by substitution of α-methoxyamides with trimethylsilyl cyanide and in an alternative route via oxidation of amidoalkylationproducts of the α-methoxyamides.
Compound as apoptosis protein inhibitor, and application thereof
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Paragraph 0285; 0287; 0288; 0289, (2018/09/12)
The present invention belongs to the field of medical chemistry, relates to a class of compounds of apoptosis protein inhibitors, and applications thereof, and particularly provides a compound represented by a formula I, or an isomer thereof, a pharmaceut
Heterocyclic core analogs of a direct thrombin inhibitor
Blizzard, Timothy A.,Singh, Sanjay,Patil, Basanagoud,Chidurala, Naresh,Komanduri, Venukrishnan,Debnath, Samarpita,Belyakov, Sergei,Crespo, Alejandro,Struck, Alice,Kurtz, Marc,Wiltsie, Judyann,Shen, Xun,Sonatore, Lisa,Arocho, Marta,Lewis, Dale,Ogletree, Martin,Biftu, Tesfaye
, p. 1111 - 1115 (2014/03/21)
Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles were p