106833-83-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-PHENYLOXAZOLE-5-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of drugs with potential antimicrobial, antiviral, and anticancer properties. Its presence in drug molecules can enhance their therapeutic effects and target specific biological pathways.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2-PHENYLOXAZOLE-5-CARBOXYLATE is used as a component in the creation of pesticides and other agrochemicals, capitalizing on its antimicrobial properties to protect crops and enhance agricultural productivity.
Used in Scientific Research:
METHYL 2-PHENYLOXAZOLE-5-CARBOXYLATE serves as a valuable compound in scientific research, where it is explored for its potential pharmacological applications and its role in the development of new chemical entities with therapeutic relevance.
Used in Chemical Synthesis:
As a building block in chemical synthesis, METHYL 2-PHENYLOXAZOLE-5-CARBOXYLATE is used to construct a variety of complex organic molecules, leveraging its reactivity to form novel compounds with potential applications in various fields.

InChI:InChI=1/C11H9NO3/c1-14-11(13)9-7-12-10(15-9)8-5-3-2-4-6-8/h2-7H,1H3

Upstream product

• 495-18-1 Benzohydroxamic acid 
• 20662-88-8 2-phenyloxazole 
• 62183-17-9 (Z)-methyl 3-(benzamido)acrylate 
• 55-21-0 benzamide 
• 98-88-4 benzoyl chloride 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 92629-11-3 5-bromo-2-phenyl-1,3-oxazole 
• 62183-16-8 methyl (E)-3-benzamidoacrylate 
• 89928-06-3 methyl ester of 3-(N-benzoyl)aminopropionic acid 
• 92629-13-5 2?phenyloxazole?5?carbaldehyde 
• 64125-07-1 methyl α-(3-phenyl-1,4,2-dioxazol-5-yl)-propionate 
• 312325-42-1 (E)-3-{[1-Hydroxy-1-phenyl-meth-(Z)-ylidene]-aminooxy}-acrylic acid methyl ester 
• 312325-43-2 (Z)-3-{[1-Hydroxy-1-phenyl-meth-(Z)-ylidene]-aminooxy}-acrylic acid methyl ester 

Downstream Products

• 39819-42-6 amide of 2-phenyloxazole-5-carboxylic acid 
• 106833-92-5 2'-Phenyl-2,5'-bioxazole 
• 106833-86-7 4,5-Dihydro-2'-phenyl-2,5'-bioxazole 
• 106833-79-8 2-phenyl-1,3-oxazole-5-carboxylic acid 
• 106833-87-8 N-(2-Hydroxyethyl)amide of 2-phenyloxazole-5-carboxylic acid 

Relevant academic research and scientific papers

SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.

A rapid access to substituted oxazoles via PIFA-mediated oxidative cyclization of enamides

A facile and rapid access to multi-substituted oxazoles has been achieved under mild reaction conditions in a short reaction time. Reaction of enamides 1 with [bis(trifluoroacetoxy)iodo]benzene (PIFA) in trifluoroethanol (TFE) at room temperature for 15?min afforded the desired oxazoles 2 in moderate to excellent yields (58–98%). A wide range of functional group tolerance has been observed for these transformations.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

Synthesis of substituted oxazoles from enamides

Annulation of enamides into 2,5- and 2,4,5-substituted oxazoles by NBS/Me2S in the presence of mild base has been achieved. The reaction conditions are simple and tolerant to a wide variety of substituents including both electron-donating and withdrawing groups to produce oxazoles in one-pot without further purification of the intermediate.

Access to di- and trisubstituted oxazoles by NBS-mediated oxidative cyclisation of N-acyl amino acid derivatives

A remarkably simple method for the synthesis of di- and trisubstituted functionalised oxazoles under metal- and catalyst-free conditions is described. An iterative bromination and debromination of N-acylated amino acid derivatives with NBS as the sole rea

Benzohydroxamic acid addition to propiolate esters - A reinvestigation

Addition of benzohydroxamic acid to propiolate esters gives 1,4,2-diozaxoles which originate, by base-catalysed ring opening with NaH, the isomeric O-vinyl hydroxamic acids. These compounds on thermolysis afford 1,3-oxazoles. (C) 2000 Elsevier Science Ltd.

SYNTHESIS, STRUCTURE, AND SPECTRAL PROPERTIES OF SOME BIOXAZOLES

Syntheses of systems containing two oxazole rings from aldehydes obtained by formylating 2-phenyl-, 2-(2-furyl)-, and 2-(2-thienyl)oxazole have been developed.Terephthalate and thiophen-2,5-dicarboxylate esters have been used to obtain 2,2'-(1,4-phenylene)- and 2,2'-(2,5-thienylene)bisoxazoles.The PMR, UV, and luminescence spectra of these systems have been examined, and quantum chemical calculations carried out in the PPP approximation.