106869-10-7

Basic information

• Product Name: FPA 138
• Synonyms: FPA 138
• CAS NO: 106869-10-7
• Molecular Weight: 275.31
• Mol File: 106869-10-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: FPA 138(CAS DataBase Reference)
• NIST Chemistry Reference: FPA 138(106869-10-7)
• EPA Substance Registry System: FPA 138(106869-10-7)

Safety Data

• Hazardous Substances Data: 106869-10-7(Hazardous Substances Data)

Upstream product

• 91-63-4 2-methylquinoline 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 5470-96-2 quinoline 2-carbaldehyde 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 1261372-59-1 [Mn(quinoline-2-carbaldehyde benzoyl hydrazone)Cl₂] 
• 59821-13-5 2-phenyl-5-(quinolin-2-yl)-1,3,4-oxadiazole 

Relevant articles and documents

Syntheses, structures, and photophysical properties of ZnII and CdII metal complexes based on benzoylhydrazones

Novel ligands were synthesized by the reaction of benzazine-2-carbaldehydes or methyl pyrazinyl ketone with benzhydrazide, as well as their ZnII and CdII complexes with the N,N,O environment. Their structures and photophysical proper

Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells

We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-

Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.