106877-20-7

Basic information

• Product Name: 3-Methoxy-4-(trifluoromethyl)phenylamine
• Synonyms: 3-Methoxy-4-(trifluoromethyl)phenylamine;3-Methoxy-4-(trifluoromethyl)
• CAS NO: 106877-20-7
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.1504296
• Mol File: 106877-20-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 49-50°
• Boiling Point: 257.0±40.0 °C at 760 mmHg
• Flash Point: 109.3±27.3 °C
• Appearance: /
• Density: 1.3±0.1 g/cm3
• Vapor Pressure: 0.0±0.5 mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: 3-Methoxy-4-(trifluoromethyl)phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-4-(trifluoromethyl)phenylamine(106877-20-7)
• EPA Substance Registry System: 3-Methoxy-4-(trifluoromethyl)phenylamine(106877-20-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 106877-20-7(Hazardous Substances Data)

Usage

General Description

3-Methoxy-4-(trifluoromethyl)phenylamine is a chemical compound with the molecular formula C8H8F3NO. It is a pale yellow solid with a molecular weight of 193.15 g/mol. 3-Methoxy-4-(trifluoromethyl)phenylamine is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It is also used as an intermediate in the production of agrochemicals and dyes. 3-Methoxy-4-(trifluoromethyl)phenylamine is a versatile compound with a wide range of applications in the fields of chemistry and pharmacology.

InChI:InChI=1S/C8H8F3NO/c1-13-7-4-5(12)2-3-6(7)8(9,10)11/h2-4H,12H2,1H3

Upstream product

• 75-63-8 Bromotrifluoromethane 
• 536-90-3 m-Anisidine 
• 453560-74-2 2-methoxy-4-nitro-1-(trifluoromethyl)benzene 
• 5458-84-4 2-iodo-5-nitroanisole 
• 2597-56-0 4-nitro-o-anisic acid 
• 276861-63-3 3-methoxy-4-(trifluoromethyl)benzoic acid 
• 887144-94-7 Togni's reagent II 

Downstream Products

• 694514-19-7 2-bromo-5-methoxy-4-(trifluoromethyl)aniline 
• 1257832-39-5 N-[4-[8-(2,4-dioxopyrimidin-1-yl)-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 
• 1257832-33-9 N-[4-[8-bromo-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 
• 1485749-11-8 tert-butyl N-[3-[4-(methanesulfonamido)phenyl]-5-methoxy-6-(trifluoromethyl)-8-quinolyl]carbamate 
• 1485749-14-1 N-[4-[8-amino-5-methoxy-6-(trifluoromethyl)-3-quinolyl]phenyl]methanesulfonamide 

Relevant articles and documents

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.