106877-48-9

Basic information

• Product Name: 2-aMino-3-(trifluoroMethyl)phenol
• Synonyms: 2-aMino-3-(trifluoroMethyl)phenol
• CAS NO: 106877-48-9
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.1238496
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 106877-48-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 229.1 °C at 760 mmHg
• Flash Point: 92.3 °C
• Appearance: /
• Density: 1.432 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.75±0.10(Predicted)
• CAS DataBase Reference: 2-aMino-3-(trifluoroMethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-3-(trifluoroMethyl)phenol(106877-48-9)
• EPA Substance Registry System: 2-aMino-3-(trifluoroMethyl)phenol(106877-48-9)

Safety Data

• Hazardous Substances Data: 106877-48-9(Hazardous Substances Data)

Usage

Description

2-Amino-3-(trifluoromethyl)phenol is an organic compound characterized by the presence of an amino group, a trifluoromethyl group, and a phenol group. It is a versatile intermediate in the synthesis of various pharmaceutical compounds and can also be used in the preparation of pesticides.

Uses

Used in Pharmaceutical Industry:
2-Amino-3-(trifluoromethyl)phenol is used as an intermediate in the synthesis of pharmaceutical compounds, particularly inhibitors. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Pesticide Industry:
2-Amino-3-(trifluoromethyl)phenol is used in the preparation of pesticides with a trifluoromethyl moiety. Its presence in these compounds can enhance their effectiveness in controlling pests and improving crop yields.

Upstream product

• 1431458-25-1 2,6-difluoro-N-(2-hydroxy-6-(trifluoromethyl)phenyl)benzamide 
• 386-72-1 2-nitro-3-(trifluoromethyl)phenol 
• 75-63-8 Bromotrifluoromethane 
• 95-55-6 2-amino-phenol 

Relevant articles and documents

Synthesis of 2-aminophenols and heterocycles by Ru-catalyzed C-H mono- and dihydroxylation

A novel and efficient synthesis of 2-aminophenols, 2-aminobenzene-1,3- diols, and heterocycles through Ru-catalyzed C-H mono- and dihydroxylation of anilides has been developed with a new directing group strategy. The reaction demonstrates excellent reactivity, regioselectivity, good functional group tolerance, and high yields.

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.