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Relevant academic research and scientific papers

Base-promoted, CBr4-mediated tandem bromination/intramolecular Friedel-Crafts alkylation ofN-aryl enamines: a facile access to 1H- And 3H-indoles

Described here is a general and highly efficient method for the synthesis of 1H- and 3H-indoles. In the presence of CBr4and a suitable base, the cyclization ofN-aryl enamines proceeds with high efficiency. Unlike previous intramolecular cross d

Synthesis of Unprotected and Highly Substituted Indoles by the Ruthenium(II)-Catalyzed Reaction of Phenyl Isocyanates with Diaryl/Diheteroaryl Alkynes/Ethyl-3-phenyl Propiolates

A one-pot transformation has been developed for the synthesis of unprotected and highly substituted indoles by an in situ installed carbamide-directed Ru(II)-catalyzed intermolecular oxidative annulation of phenyl isocyanates with diaryl/diheteroaryl alkynes/ethyl phenyl propiolates in the presence of Cu(OAc)2·H2O as an oxidant and AgSbF6 as an additive at 120 °C within 3 h.

Copper-Mediated One-Pot Synthesis of Indoles through Sequential Hydroamination and Cross-Dehydrogenative Coupling Reaction

Starting from simple anilines and ester arylpropiolates, an efficient one-pot synthesis of 2-arylindole-3-carboxylate derivatives has been developed through copper-mediated sequential hydroamination and cross-dehydrogenative coupling (CDC) reaction. The i

Copper-Catalyzed Synthesis of Multisubstituted Indoles through Tandem Ullmann-Type C-N Formation and Cross-dehydrogenative Coupling Reactions

Multisubstituted indoles were synthesized via a one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process at 130 °C in DMSO. The methodology allows practical and modular assembly of indoles in go

Electrocatalytic intramolecular oxidative annulation of: N -aryl enamines into substituted indoles mediated by iodides

An electrocatalytic reaction protocol is developed for achieving intramolecular dehydrogenative annulation of N-aryl enamines. It offers a simple and efficient way for the synthesis of indoles in an undivided cell. Good to excellent yields are obtained un

Visible Light Promoted Synthesis of Indoles by Single Photosensitizer under Aerobic Conditions

The construction of substituted indole skeletons is always an important concern of synthetic chemists because of its prevalent structure found in natural products and biological molecules. Here, we succeeded in preparing indoles and their derivatives from

Synthesis of 2,3-Disubstituted NH Indoles via Rhodium(III)-Catalyzed C-H Activation of Arylnitrones and Coupling with Diazo Compounds

A rhodium-catalyzed intermolecular coupling between arylnitrones and diazo compounds by C-H activation/[4 + 1] annulation with a C(N2)-C(acyl) bond cleavage is reported, and 2,3-disubstituted NH indoles are directly synthesized in up to a 94% yield. A variety of functional groups are applicable to this reaction to give the corresponding products with high selectivity. Compared to other previously reported Rh(III)-catalyzed synthesis of homologous series, this method is simpler, more general, and more efficient.

An Oxidant-Free Strategy for Indole Synthesis via Intramolecular C-C Bond Construction under Visible Light Irradiation: Cross-Coupling Hydrogen Evolution Reaction

We describe here an oxidant-free strategy to synthesize indoles, i.e., under visible-light irradiation (λ = 450 nm), catalytic amounts of an iridium(III) photosensitizer and cobaloxime catalyst transform various N-aryl enamines exclusively into indoles. O

Selective Synthesis of Indoles by Cobalt(III)-Catalyzed C-H/N-O Functionalization with Nitrones

The redox-neutral annulation of alkynes by differently decorated nitrones set the stage for a step-economical access to indoles with ample substrate scope. The redox-neutral C-H/N-O functionalization process proceeded through kinetically relevant C-H activation by carboxylate assistance, and displayed an excellent site- and regio-selectivity with unsymmetrical nitrones and alkynes.

Iodide-Ion-Catalyzed carbon-carbon bond-forming cross-dehydrogenative coupling for the synthesis of indole derivatives

The nBu4NI-catalyzed intramolecular cross-dehydrogenative coupling (CDC) reaction has been applied to the synthesis of 1H-indole derivatives. Intramolecular oxidative coupling of N-arylenamines proceeded in the presence of a catalytic amount of nBu4NI and tert-butyl hydroperoxide (TBHP) to afford the corresponding 1H-indole derivatives in good-to-excellent yields. A preliminary study of the synthesis of 3H-indole is also reported. This is a rare example of the nBu4NI-catalyzed C-C bond-forming CDC reaction. Copyright