682777-27-1Relevant articles and documents
A convergent preparation of the C1-C13 fragment of amphotericin B from a single chiral precursor
Bonini, Carlo,Chiummiento, Lucia,Martuscelli, Angela,Viggiani, Licia
, p. 2177 - 2179 (2004)
A short, highly efficient, stereoconvergent synthesis of the polyolic chain, C1-C13, of the macrolide antibiotic amphotericin B is described. The key features of the synthesis are the use of a single chiral precursor for the establishment of the stereogenic centres in a short synthetic sequence, and the final alkyl lithium addition to the appropriate aldehyde, which showed high diastereoselectivity for the correct stereochemistry at the fifth stereogenic centre.