107177-97-9

Basic information

• Product Name: Pyridine, 3-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-
• CAS NO: 107177-97-9
• Molecular Formula: C19H14N4
• Molecular Weight: 298.347
• Mol File: 107177-97-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-(107177-97-9)
• EPA Substance Registry System: Pyridine, 3-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)-(107177-97-9)

Safety Data

• Hazardous Substances Data: 107177-97-9(Hazardous Substances Data)

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 313650-72-5 C₁₉H₁₈N₄ 
• 588-64-7 benzaldehyde phenylhydrazone 
• 918497-00-4 α-chlorobenzaldehyde phenylhydrazone 
• 313650-72-5 C₁₉H₁₈N₄ 

Relevant articles and documents

Design and synthesis of 1,3,5-trisubstituted 1,2,4-triazoles as CYP enzyme inhibitors

A series of 1,3,5-trisubstituted 1,2,4-triazoles was designed and synthesized as potential inhibitors of ste-roidogenic CYP enzymes. The 1,2,4-triazole is part of the core structure fixing the geometry of the substances. A pyridine moiety was introduced as heme-binder. The target compounds were synthesized in two to four steps using silver carbonate mediated ring closure and Suzuki cross coupling reaction as key synthetic transformations. Biological testing of the synthesized compounds for the inhibition of the most important steroidogenic CYPs revealed compounds 29a and 30 as moderate inhibitors of aldo-sterone synthase (CYP11B2).

An improved synthesis of 1,2,4-triazoles using Ag2CO3

An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the β-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd.