1072913-50-8Relevant academic research and scientific papers
Catalytic one-pot microwave assisted synthesis of 4-azapodophyllotoxin derivatives and rational design of experiment
Chang, Peng,Aillerie, Alexandre,Kosmala, Marion,Pellegrini, Sylvain,Bousquet, Till,Bigan, Muriel,Pélinski, Lydie
, p. 8236 - 8239 (2015)
A catalytic one-pot microwave assisted synthesis of 4-azapodophyllotoxin has been described. Rational design of experiment has been used to obtain the reaction yield.
Cascade synthesis of 3-quinolinecarboxylic ester via benzylation/ propargylation-cyclization
Fan, Jinmin,Wan, Changfeng,Sun, Gaojun,Wang, Zhiyong
scheme or table, p. 8608 - 8611 (2009/04/04)
(Chemical Equation Presented) Reactions of 2-amino-aryl alcohols with β-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation- cyclization, 2-nitrophenyl propargyl alcohols with β-ketoesters catalyzed by FeCl3 and SnCl2 also produce the 4-alkyne-3- quinolinecarboxylic esters. The mechanistic details of this benzylation/ propargylation and cyclization cascade process are also discussed.
