17282-90-5

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 81783-47-3 2-amino-benzophenone O-methyl oxime 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 100-47-0 benzonitrile 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 1072913-50-8 ethyl 2,4-diphenyl-1,4-dihydroquinoline-3-carboxylate 

Relevant academic research and scientific papers

An efficient heterogeneous gold(I)-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes leading to polyfunctionalized quinolines

The first heterogeneous intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes was realized in DMF at 100 °C by using a triphenylphosphine-functionalized MCM-41-supported gold(I) complex [MCM-41-PPh3-AuCl] and AgOTf as catal

Regioselective intramolecular annulations of ambident β-enamino esters: A diversity-oriented synthesis of nitrogen-containing privileged molecules

Diversity-oriented, regioselective, intramolecular annulation of β-enamino esters is described under solvent-free, calcium-catalysis. 2-aminoaryl ketones and alkyl propiolates undergone a [4+2] annulation to yield substituted quinolines; with an excess of

Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents

Sodium trifluoromethanesulfonate, and glacial acetic acid selectively catalyzed the synthesis of dihydroquinoline via Friedl?nder annulation. The synthesized dihydroquinoline analogues coupled with different amines by the use of coupling reagent gave dihy

Solid-Phase Friedl?nder Synthesis Using an Alkoxyamine Linker

A quinoline library was prepared by combinatorial synthesis using an alkoxyamine linker. Substrates were loaded onto a solid support containing an oxime linkage. After selected reactions on the solid support, the products were cleaved by a Friedl?nder-typ

Palladium-catalyzed synthesis of polysubstituted quinolines from 2-amino aromatic ketones and alkynes

A palladium-catalyzed one-pot method for the synthesis of quinolines from commercial or readily available 2-amino aromatic ketones and alkynes is reported for the first time. This transformation offers an alternative method for the synthesis of polysubstituted quinoline. the Partner Organisations 2014.

Synthesis of polysubstituted quinolines via copper(ii)-catalyzed annulation of 2-aminoaryl ketones with alkynoates

Copper triflate catalyzed annulation of 2-aminoaryl ketones with internal alkynes has been developed for the synthesis of polysubstituted quinolines in high yields under solvent-free conditions. Phenyl propiolic acid afforded the 3-unsubstituted quinoline

Copper(II)-catalyzed three-component cascade annulation of diaryliodoniums, nitriles, and alkynes: A regioselective synthesis of multiply substituted quinolines

Three become one: Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a CuII-catalyzed method. This cascade annulation is highly regioselective, step-economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules. Copyright

Chitosan-SO3H: An efficient, biodegradable, and recyclable solid acid for the synthesis of quinoline derivatives via Friedl?nder annulation

Chitosan-SO3H is found to catalyze the Friedl?nder condensation/annulation reaction of 2-aminoaryl ketones with α-methyleneketones to produce the corresponding quinoline derivatives in high yields in short reaction times. The use of recyclable

Efficient synthesis of 2,3,4-trisubstituted quinolines via friedl?nder annulation with nanoporous cage-type aluminosilicate AlKIT-5 catalyst

2-Aminoaryl ketones undergo smooth Friedl?nder condensation/annulation with α-methyleneketones on the surface of nanoporous aluminosilicate catalyst to afford the corresponding quinoline derivatives in good yields with high selectivity due to its high sur

Cascade synthesis of 3-quinolinecarboxylic ester via benzylation/ propargylation-cyclization

(Chemical Equation Presented) Reactions of 2-amino-aryl alcohols with β-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation- cyclization, 2-nitrophenyl propargyl alcohols with β-ketoesters catalyzed by FeCl3 and SnCl2 also produce the 4-alkyne-3- quinolinecarboxylic esters. The mechanistic details of this benzylation/ propargylation and cyclization cascade process are also discussed.