107411-17-6

Basic information

• Product Name: 4-Hydroxy-benzilsaeure
• Synonyms: 4-Hydroxy-benzilsaeure
• CAS NO: 107411-17-6
• Molecular Weight: 244.247
• Mol File: 107411-17-6.mol

Chemical Properties

• CAS DataBase Reference: 4-Hydroxy-benzilsaeure(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-benzilsaeure(107411-17-6)
• EPA Substance Registry System: 4-Hydroxy-benzilsaeure(107411-17-6)

Safety Data

• Hazardous Substances Data: 107411-17-6(Hazardous Substances Data)

Upstream product

• 38469-73-7 1-(4-hydroxyphenyl)-2-phenylethan-1,2-dione 
• 76-93-7 Benzilic acid 
• 3608-67-1 N-methyl-4-piperidyl benzilate 
• 124-38-9 carbon dioxide 
• 1137-42-4 4-Hydroxybenzophenone 
• 2491-32-9 1-(4-Hydroxyphenyl)-2-phenylethanone 
• 4237-50-7 4-methoxybenzilic acid 
• 108-95-2 phenol 

Relevant articles and documents

Photocatalytic Carbinol Cation/Anion Umpolung: Direct Addition of Aromatic Aldehydes and Ketones to Carbon Dioxide

We have developed a new photocatalytic umpolung reaction of carbonyl compounds to generate anionic carbinol synthons. Aromatic aldehydes or ketones reacted with carbon dioxide in the presence of an iridium photocatalyst and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole (DMBI) as a reductant under visible-light irradiation to furnish the corresponding α-hydroxycarboxylic acids through nucleophilic addition of the resulting carbinol anions to electrophilic carbon dioxide.

Biomimetic investigations of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate

The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)-β-tetrasulfonat oporphyrin chloride (MnTPFPS4PCl)/imidazole/hydrogen peroxide in aqueous solution at pH 7-8 affords unchanged 1 and 2 and numerous metabolites, which are products of fission of the ester bond, of O-dealkylation, decarboxylation, N-demethylation, and oxidation of the tertiary amine function. In contrast to the nonaqueous system with the catalyst manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl) aromatic hydroxylation is not observed. This result shows conformity with the studies of metabolism in men.

Biomimetic oxidation of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate

The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/pyridine/hydrogen peroxide affords unchanged 1 and 2 and 15 potential metabolites, which were isolated and identified. These compounds are products of cleavage of the ester bond, of O-dealkylation, aromatic oxidation, respectively of decarboxylation, demethylation, and N-oxidation. Products were identified by TLC, UV, and MS in comparison with authentic samples. Thereby we found a nearly conformity with rat metabolism.