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1-(4-Hydroxyphenyl)-2-phenylethan-1,2-dion is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

38469-73-7

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38469-73-7 Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 2119, 1994 DOI: 10.1080/00397919408010224

Check Digit Verification of cas no

The CAS Registry Mumber 38469-73-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,4,6 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 38469-73:
(7*3)+(6*8)+(5*4)+(4*6)+(3*9)+(2*7)+(1*3)=157
157 % 10 = 7
So 38469-73-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H10O3/c15-12-8-6-11(7-9-12)14(17)13(16)10-4-2-1-3-5-10/h1-9,15H

38469-73-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-hydroxyphenyl)-2-phenylethane-1,2-dione

1.2 Other means of identification

Product number -
Other names 1-(4-hydroxyphenyl)-2-phenyl-1,2-ethanedione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38469-73-7 SDS

38469-73-7Relevant academic research and scientific papers

Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities

Yayli, Nurettin,Kili?, G?zde,Celik, Gonca,Kahriman, Nuran,Kanbolat, Seyda,Bozdeveci, Arif,Karaoglu, Sengül Alpay,Aliyazicioglu, Rezzan,Sellitepe, Hasan Erdin?,Dogan, Inci Selin,Aydin, Ali

, p. 788 - 804 (2021/07/26)

In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four diffe

Visible light-induced aerobic oxidation of diarylalkynes to α-diketones catalyzed by copper-superoxo at room temperature

Charpe, Vaibhav Pramod,Hwang, Kuo Chu,Sagadevan, Arunachalam

supporting information, p. 4426 - 4432 (2020/08/10)

We have developed the visible light induced simple copper(ii) chloride catalyzed oxidation of diarylacetylenes to α-diketones by molecular oxygen at room temperature. The in situ generated copper(ii)-superoxo complex is a light-absorbing species that oxidizes inert diarylacetylenes to α-diketones. In contrast to reported photochemical processes, the current oxidation protocol does not require any exogenous photocatalyst or radical initiator. The green chemistry metrics evaluation signifies that the E-factor for the current oxidation process is ~2.3 times better than that of reported photochemical processes. The current reaction scores 63 on the EcoScale of 0-100, indicating an adequate synthesis process. Thus, the overall oxidation process is simple, environmentally benign, and economically feasible. This journal is

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives

Schw?rzer, Kuno,Bellan, Andreas,Z?schg, Maximilian,Karaghiosoff, Konstantin,Knochel, Paul

, p. 9415 - 9418 (2019/05/10)

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.

Metal-Free Iodine-Catalyzed Oxidation of Ynamides and Diaryl Acetylenes into 1,2-Diketo Compounds

Kim, Seung Woo,Um, Tae-Woong,Shin, Seunghoon

supporting information, p. 4703 - 4711 (2018/04/26)

Metal-free oxidation of ynamides is described, employing pyridine-N-oxides as oxidants under molecular iodine catalysis. In stark contrast to Br?nsted acid catalysis, iodophilic activation of ynamides diverts the reaction manifold into a dioxygenation pathway. This oxidation is very rapid at room temperature with only 2.5 mol % I2. Furthermore, this protocol could be extended to nonactivated alkynes, such as diarylacetylenes, to deliver various benzil derivatives.

Direct Construction of 4-Hydroxybenzils via Para-Selective C-C Bond Coupling of Phenols and Aryl Methyl Ketones

Xiang, Jia-Chen,Cheng, Yan,Wang, Miao,Wu, Yan-Dong,Wu, An-Xin

supporting information, p. 4360 - 4363 (2016/10/09)

A highly para-selective C-C bond coupling is presented between phenols C(sp2) and aryl methyl ketones C(sp3), which enables the direct construction of 4-hydroxybenzil derivatives. This practical method exhibits a broad substrate scop

β-Cyclodextrin/IBX in water: Highly facile biomimetic one pot deprotection of THP/MOM/Ac/Ts ethers and concomitant oxidative cleavage of chalcone epoxides and oxidative dehydrogenation of alcohols

Kumar, Sumit,Ahmed, Naseem

supporting information, p. 648 - 656 (2016/02/12)

A mild and efficient one-pot deprotection of THP/MOM/Ac/Ts ethers, and concomitant oxidative cleavage of epoxides and oxidative dehydrogenation of alcohols to form β-hydroxy 1,2-diketones, 1,2,3-triketones and conjugated aromatic carbonyl systems (chalcones) using β-cyclodextrin/IBX in water has been developed. o-Iodoxybenzoic acid, a readily available hypervalent iodine(v) reagent, was found to be highly effective with β-cyclodextrin in carrying out the deprotection and subsequent transformations under an eco-friendly environment. The reaction gave moderate to excellent yields ranging from 50-99% at 60°C in 40 min to 6 h.

Gold-Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols

Zhao, Jidong,Liu, Jun,Xie, Xin,Li, Shi,Liu, Yuanhong

supporting information, p. 5926 - 5929 (2015/12/11)

A new and convenient strategy for the synthesis of functionalized tropone derivatives based on the gold-catalyzed oxidative ring expansion of alkynyl quinols has been developed. The reaction proceeds via gold-catalyzed highly regioselective oxidation foll

Synthesis of α-diketones from alkylaryl- and diarylalkynes using mercuric salts

Jung, Michael E.,Deng, Gang

supporting information, p. 2142 - 2145 (2014/05/06)

Both alkylarylalkynes and diarylalkynes 1 are converted into the α-diketones 2 in good yield by the use of mercuric salts, e.g., mercuric nitrate hydrate or mercuric triflate, in the presence of water. Other mercuric salts, e.g., sulfate, chloride, acetate, or trifluoroacetate, do not provide the diketone product. A possible mechanism is proposed.

Transition metal-free oxidation of ynamides for synthesis of α-keto-imides

Chikugo, Takuya,Yauchi, Yuta,Ide, Masataka,Iwasawa, Tetsuo

, p. 3988 - 3993 (2014/06/09)

Transition metal-free double oxidation of triple bonds in ynamides for synthesis of α-keto-imides is described. The successful key was combination of NIS and DMSO under atmospheric air in CPME solvent, and the reaction quickly proceeds at 0 °C within 1 h.

Design, synthesis, and cytotoxic activities of new 2,4,5-triarylimidazoles

Zarghi,Arfaei,Shirazi

, p. 3897 - 3904 (2013/07/26)

A new group of 2,4,5-triarylimidazoles containing N,N-dimethylaminoethoxy or piperidinyl ethoxy group at the para position of the C-5 phenyl ring were synthesized and their cytotoxic activities were evaluated on three different breast cancer cell lines using MTT assay. The compounds contain various substituents at the para position of C-2 phenyl ring. Among the synthesized compounds, 4-(5-(4-(2-piperidin-1-yl)ethoxy)phenyl)-4-phenyl-1H-imidazol-2-yl) phenol (11e) and 1-2-(4-(2,4-diphenyl-1H-imidazol-5-yl)phenoxy)ethyl) piperidine (11h) with IC50s of less than 0.1 μM on all three cell lines were the most potent cytotoxic compounds.

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