107416-50-2

Usage

Uses

Used in Pharmaceutical Industry:
PHENYL-PIPERIDIN-1-YL-ACETIC ACID HYDROCHLORIDE is used as an antidiarrheal agent for its ability to slow down intestinal movement, which helps in reducing the frequency and urgency of bowel movements. This makes it a suitable treatment for diarrhea, providing relief to patients experiencing this condition.
Used in Medical Treatments:
PHENYL-PIPERIDIN-1-YL-ACETIC ACID HYDROCHLORIDE is utilized as a therapeutic agent for managing diarrhea due to its high affinity for mu-opioid receptors in the intestine, which contributes to its effectiveness in controlling intestinal motility and alleviating the symptoms of diarrhea. It is important to follow the prescribed dosage to prevent misuse and potential adverse effects.

Upstream product

• 7550-06-3 ethyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 776-75-0 N-benzoylpiperidine 
• 98-88-4 benzoyl chloride 
• 110-89-4 piperidine 
• 5766-79-0 2-phenyl-2-piperidinoacetonitrile 

Downstream Products

• 1446307-75-0 (R)-quinuclidin-3-yl 2-phenyl-2-(piperidin-1-yl)acetate 

Relevant academic research and scientific papers

Straightforward α-Amino Nitrile Synthesis Through Mo(CO)6-Catalyzed Reductive Functionalization of Carboxamides

The selective reduction of amides into an intermediate hemiaminal catalyzed by Mo(CO)6 together with the inexpensive and easy to handle TMDS (1,1,3,3-tetramethyldisiloxane) as reducing agent, followed by subsequent trapping of the hemiaminal with a cyanide source, allows for the straightforward synthesis of α-amino nitriles. The methodology presented here, displays high levels of chemoselectivity allowing for the reduction of amides in the presence of functional groups such as ketones, imines, aldehydes, and acids, which affords a simple route for the synthesis of α-amino nitriles with a broad scope of functionalities in high yields. Furthermore, the applicability of this methodology is demonstrated by scale up experiments and by derivatization of the target compounds into synthetically interesting products. The selective cyanation is successfully applied in late stage functionalizations of amide containing drugs and prolinol derivatives.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at positions 3 and 5, respectively, establishing a novel chemical class culminating in identification of 72 (CFI-400936). This potent inhibitor of TTK (IC50 = 3.6 nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases. A co-complex TTK X-ray crystal structure and results of a xenograft study with TTK inhibitors from this class are described.

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

The invention relates to compounds of formula (I), wherein A, R1, R2, X, m and n are as defined in the specification, as selective M3 receptor antagonists, process for their preparation, composition comprising them and the therapeutic use thereof. Said co

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.