7550-06-3Relevant articles and documents
Synthesis and characterization of bisoxazolines- and pybox-copper(II) complexes and their application in the coupling of α-carbonyls with functionalized amines
Jia, Wei-Guo,Li, Dan-Dan,Dai, Yuan-Chen,Zhang, Hui,Yan, Li-Qin,Sheng, En-Hong,Wei, Yun,Mu, Xiao-Long,Huang, Kuo-Wei
supporting information, p. 5509 - 5516 (2014/07/21)
Binuclear complexes [{(DMOX)CuCl}2(μ-Cl)2] (1), mononuclear complexes [(DMOX)CuBr2] (2) (DMOX = 4,5-dihydro-2-(4,5- dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyloxazole) and the pybox Cu(ii) complex [(Dm-Pybox)CuBr2/
Copper activation of boronic acids: Factors affecting reactivity
Frauenlob, Robin,Garcia, Carlos,Butler, Susan,Bergin, Enda
, p. 432 - 435 (2014/06/09)
The generation of nucleophiles from the combination of aryl boronic acids and catalytic amounts of copper salt allows a reactivity distinct from other organometallic species, such as organolithiums or Grignard reagents. Here we examine how the electronic
QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF
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Page/Page column 26-27, (2013/07/19)
The invention relates to compounds of formula (I), wherein A, R1, R2, X, m and n are as defined in the specification, as selective M3 receptor antagonists, process for their preparation, composition comprising them and the therapeutic use thereof. Said co
QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF
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Paragraph 0108; 0109; 0110, (2013/07/19)
Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.
A copper-catalyzed petasis reaction for the synthesis of tertiary amines and amino esters
Frauenlob, Robin,Garcia, Carlos,Bradshaw, Gary A.,Burke, Helen M.,Bergin, Enda
experimental part, p. 4445 - 4449 (2012/06/18)
We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studi
A Straightforward Three-Component Synthesis of α-Amino Esters Containing a Phenylalanine or a Phenylglycine Scaffold
Haurena, Caroline,Le Gall, Erwan,Sengmany, Stephane,Martens, Thierry,Troupel, Michel
supporting information; experimental part, p. 2645 - 2650 (2010/07/02)
A range of α-amino esters has been synthesized in good to high yields using a straightforward three-component reaction among preformed or in situ generated aromatic or benzylic organozinc reagents, primary or secondary amines, and ethyl glyoxylate. The procedure, which is characterized by its simplicity, allows the concise synthesis of esters bearing a phenylglycine or a phenylalanine scaffold.
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 50, (2008/12/04)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
A concise three-component synthesis of α-amino esters derived from phenylglycine and phenylalanine
Haurena, Caroline,Sengmany, Stéphane,Huguen, Paul,Gall, Erwan Le,Martens, Thierry,Troupel, Michel
body text, p. 7121 - 7123 (2009/04/10)
α-Amino esters have been synthesized using a straightforward three-component reaction among preformed or in situ-generated aromatic or benzylic organozinc reagents, primary or secondary amines and ethyl glyoxylate. The procedure, which is characterized by its simplicity, allows the concise synthesis of phenylglycine and phenylalanine derivatives.
Ruthenium-catalyzed one-pot carbenoid N-H insertion reactions and diastereoselective synthesis of prolines
Deng, Qing-Hai,Xu, Hai-Wei,Yuen, Angella Wing-Hoi,Xu, Zhen-Jiang,Che, Chi-Ming
supporting information; experimental part, p. 1529 - 1532 (2009/04/07)
Aryl- and aliphatic-substituted 3-hydroxyprolines and various other amino esters are conveniently prepared by [RuCI2(p-cymene)] 2-catalyzed one-pot intramolecular and intermolecular carbenoid N-H insertion reactions, respectively, and the prolines are formed with high diastereoselectivities. The catalytic reactions are tolerant toward air/moisture, and the product yields are insensitive to the organic solvents used.
The Chemistry of N-Substituted Benzotriazoles Part 23. Synthesis of Tertiary α-Amino Esters
Katritzky, Alan R.,Urogdi, Laszlo,Mayence, Annie
, p. 323 - 327 (2007/10/02)
2-Dialkylaminoalkanoic esters 6 are prepared in good yield by the reaction of organozinc derivatives 5 with dialkylamino(1-benzotriazolyl)acetic esters 4, obtained from the condensation of secondary amines 3 with ethyl glyoxylate 2 and benzotriazole 1.