107456-48-4

Basic information

• Product Name: N-(3-methoxyphenyl)-2-methylaniline
• Synonyms: benzenamine, N-(3-methoxyphenyl)-2-methyl-; N-(3-Methoxyphenyl)-2-methylaniline
• CAS NO: 107456-48-4
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Mol File: 107456-48-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 335.9°C at 760 mmHg
• Flash Point: 137°C
• Density: 1.089g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: N-(3-methoxyphenyl)-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxyphenyl)-2-methylaniline(107456-48-4)
• EPA Substance Registry System: N-(3-methoxyphenyl)-2-methylaniline(107456-48-4)

Safety Data

• Hazardous Substances Data: 107456-48-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 74-87-3 methylene chloride 
• 6264-98-8 3-(o-tolylamino)phenol 
• 536-90-3 m-Anisidine 
• 615-37-2 ortho-methylphenyl iodide 
• 3899-92-1 3-methoxyphenyl 4-methylbenzenesulfonate 
• 95-53-4 o-toluidine 
• 53034-26-7 m-Methoxyphenyllead(IV) triacetate 
• 95-46-5 2-methylphenyl bromide 
• 588-16-9 m-methoxyacetanilide 

Downstream Products

• 108805-68-1 (3-methoxy-4-nitroso-phenyl)-o-tolyl-amine 

Relevant articles and documents

Arylation with unsymmetrical diaryliodonium salts: A chemoselectivity study

Phenols, anilines, and malonates have been arylated under metal-free conditions with twelve aryl(phenyl)iodonium salts in a systematic chemoselectivity study. A new "anti-ortho effect" has been identified in the arylation of malonates. Several "dummy groups" have been found that give complete chemoselectivity in the transfer of the phenyl moiety, irrespective of the nucleophile. An aryl exchange in the diaryliodonium salts has been observed under certain arylation conditions. DFT calculations have been performed to investigate the reaction mechanism and to elucidate the origins of the observed selectivities. These results are expected to facilitate the design of chiral diaryliodonium salts and the development of catalytic arylation reactions that are based on these sustainable and metal-free reagents. Copyright

Aryllead Triacetates: Regioselective Reagents for N-Arylation of Amines

Aryllead triacetates have been found to be regioselective reagents for the mono N-arylation of a range of aromatic, heterocyclic and aliphatic amines under mild and neutral conditions in a reaction catalysed by copper diacetate.The arylation of arylamines was unaffected by the steric hindrance of the arylamine but was dependent on the arylamine basicity.In addition, the position of oxidisable substituents on both the aryllead triacetate and the arylamine was found to be important due to a competing oxidation-reduction reaction.The arylation of heterocyclic amines proceeded in modest to good yields whilst aliphatic amines were arylated in poor to modest yields.The mechanism proposed for these reactions involves transfer of the aryl group onto copper forming a copper(III) intermediate which subsequently undergoes ligand coupling to give the N-arylated amine and the catalytic CuI species.