107491-54-3

Basic information

• Product Name: 4-methyl-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide
• Synonyms: Benzenesulfonamide, 4-methyl-N-[4-(trifluoromethyl)phenyl]-
• CAS NO: 107491-54-3
• Molecular Formula: C₁₄H₁₂F₃NO₂S
• Molecular Weight: 315.3108
• Mol File: 107491-54-3.mol
• Article Data: 25

Chemical Properties

• Melting Point: 140-142 °C
• Boiling Point: 393.2°C at 760 mmHg
• Flash Point: 191.6°C
• Density: 1.38g/cm³
• Vapor Pressure: 2.16E-06mmHg at 25°C
• Refractive Index: 1.557
• PKA: 7.27±0.10(Predicted)
• CAS DataBase Reference: 4-methyl-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide(107491-54-3)
• EPA Substance Registry System: 4-methyl-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide(107491-54-3)

Safety Data

• Hazardous Substances Data: 107491-54-3(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 98-56-6 4-chlorobenzotrifluoride 
• 941-55-9 4-toluenesulfonyl azide 
• 77152-08-0 trifluoromethylcopper(I) 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 127-65-1 chloroamine-T 
• 455-13-0 4-Iodobenzotrifluoride 
• 455-14-1 4-trifluoromethylphenylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 158268-30-5 N-tosyl-4-iodoaniline 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1443775-44-7 N-allyl-4-methyl-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide 
• 1443775-66-3 N-(2-fluropropyl)-4-methyl-N-(4-trifluoromethylphenyl)benzenesulfonamide 

Relevant articles and documents

A simple and efficient method for sulfonylation of amines, alcohols and phenols with cupric oxide under mild conditions

Cupric Oxide efficiently catalyzed the synthesis of sulfonamides and sulfonic esters. This method has been applied to a variety of substrates including nucleophilic and sterically-hindered amines, alcohols and phenols with excellent yields of sulfonamides and sulfonic esters. The remarkable selectivity under mild and neutral conditions of this commercially available inexpensive catalyst is an attractive feature of this method.

KCC-1 aminopropyl-functionalized supported on iron oxide magnetic nanoparticles as a novel magnetic nanocatalyst for the green and efficient synthesis of sulfonamide derivatives

A new magnetic nanocatalyst (Fe3O4@KCC-1-npr-NH2) was synthesized directly through the reaction of Fe3O4@KCC-1 with (3-aminopropyl) triethoxysilane (APTES) using a hydrothermal protocol. Prepared nanocomposite was used as a magnetically reusable nanocatalyst for an efficient synthesis of a broad range of sulfonamide derivatives in water as a green solvent at room temperature and the products are collected by filtration with excellent yields (85–97%). The nanocatalyst could be remarkably recovered and reused after ten times without any significant decrease in activity. This mild and simple synthesis method offers some advantages including short reaction time, high yield and simple work-up procedure.

Mild and efficient indium metal catalyzed synthesis of sulfonamides and sulfonic esters

A facile and efficient method for synthesizing sulfonamides was developed using a catalytic amount of indium metal. A wide range of sulfonamides were synthesized in excellent yields using the new process. The method showed a generality for substrates including less nucleophilic and sterically hindered anilines, and it is also applicable for preparing sulfonic esters from sulfonyl chlorides and alcohols. Georg Thieme Verlag Stuttgart.

Carbon dot/TiO2nanocomposites as photocatalysts for metallaphotocatalytic carbon-heteroatom cross-couplings

Carbon dots have been previosly immobilized on titanium dioxide to generate photocatalysts for pollutant degradation and water splitting. Here we demonstrate that these nanocomposites are valuable photocatalysts for metallaphotocatalytic carbon-heteroatom cross-couplings. These sustainable materials show a large applicability, high photostability, excellent reusability, and broadly absorb across the visible-light spectrum.