107558-16-7

Upstream product

• 506-96-7 Acetyl bromide 
• 952-97-6 4-nitrophenyl phenyl sulfide 
• 73408-22-7 4-(4-nitro-phenylsulfanyl)-benzoyl chloride 
• 506-82-1 dimethylcadmium 
• 108-24-7 acetic anhydride 
• 7637-07-2 boron trifluoride 
• 1849-36-1 para-nitrobenzenethiol 
• 149104-90-5 4-acetylphenylboronic acid 
• 24067-17-2 4-nitrophenylboronic acid 
• 99-93-4 4-Hydroxyacetophenone 
• 64101-67-3 4-acetylphenyl p-toluenesulfonate 
• 13031-43-1 4-acetyloxyacetophenone 
• 75-36-5 acetyl chloride 
• 32676-68-9 mixed anhydride of acetic and trichloroacetic acids 

Downstream Products

• 107920-30-9 C₁₄H₁₂N₂O₃S 
• 101284-40-6 acetic acid-[4-(4-acetyl-benzenesulfonyl)-anilide] 
• 101283-64-1 acetic acid-[4-(4-acetyl-phenylsulfanyl)-anilide] 
• 100710-53-0 1-[4-(4-amino-phenylsulfanyl)-phenyl]-ethanol 
• 114617-14-0 N-[4-(4-acetyl-phenylsulfanyl)-phenyl]-diacetamide 
• 101533-62-4 1-[4-(4-nitro-benzenesulfonyl)-phenyl]-ethanone 
• 14453-89-5 1-(4-((4-aminophenyl)thio)phenyl)ethan-1-one 
• 117881-01-3 bis-[4-(4-acetyl-phenylsulfanyl)-phenyl]-diazene-N-oxide 

Relevant academic research and scientific papers

Direct C-S bond formation: Via C-O bond activation of phenols in a crossover Pd/Cu dual-metal catalysis system

A dual-metal catalysis system including a newly prepared nanoparticle [SiO2@organic-linker(OL)@Pd(II)] and CuI was introduced with ultra-high catalytic activity (high turnover number (TON), up to 19000) to a one-pot and odorless synthesis of unsymmetrical aryl sulfides by crossover C-S bond formation. The reaction proceeds via C-O bond activation of phenols and direct C-S bond formation in the presence of S8 as an oddorless sulfur source and aryl boronic acids under mild conditions (room temperature). The catalyst could be recycled up to five times without an obvious change in its activity.

Copper-Catalyzed C-S Bond Formation via the Cleavage of C-O Bonds in the Presence of S8 as the Sulfur Source

Useful and applicable methods for one-pot and odorless synthesis of unsymmetrical and symmetrical diaryl sulfides via C-O bond activation are presented. First, a new efficient procedure for the synthesis of unsymmetrical sulfides using the cross-coupling reaction of phenolic esters such as acetates, tosylates, and triflates and with arylboronic acid or triphenyltin chloride as the coupling partners is reported. Depending on the reaction, S 8 /KF or S 8 /NaO t -Bu system is found to be an effective source of sulfur in the presence of copper salts and in poly(ethylene glycol) as a green solvent. Then, the synthesis of symmetrical diaryl sulfides from phenolic compounds by using S 8 as the sulfur source and NaO t -Bu in anhydrous DMF at 120 °C under N 2 is described. By these protocols, the synthesis of a variety of unsymmetrical and symmetrical sulfides become easier than the available protocols in which thiols and aryl halides are directly used for the preparation of the sulfides.

Copper mediated formation of carbon-heteroatom bonds using organoboron reagents and ultrasound

This report summarizes research efforts focused on copper acetate mediated reactions to form new carbon-heteroatom bonds using organoboron reagents under ultrasound irradiation. The method involves the application of ultrasound irradiation to the Chan-Evans-Lam reaction to achieve O-arylation of phenols, N-arylation of anilines and indoles, and S-arylation of thiols. Ultrasound irradiation was found to decrease reaction times from 72 hours to 4 hours while improving the product yields an average of 20%.1 Representative C-O, C-N, and C-S coupling reactions were successfully scaled-up from the milligram to gram levels while maintaining good product yields offering potential applications in industrial processes.

OXIME ESTERS AND PHOTOPOLYMERIZATION INITIATORS CONTAINING THE SAME

An oxime ester compound of formula (I) useful as a photopolymerization initiator. A photopolymerization initiator having the oxime ester compound as an active ingredient is activated through efficient absorption of light of long wavelength, e.g., 405 nm or 365 nm, to exhibit high sensitivity. In formula (I), R1 and R2 are each R11, OR11, COR11, SR11, CONR12R13, or CN; R11, R12, and R13 are each hydrogen, a C1-C20 alkyl group, C6-C30 aryl group, a C7-C30 arylalkyl group, or a C2-C20 heterocyclic group; R3 and R4 are each R11, OR11, SR11, COR11, CONR12R13, NR12COR11, OCOR11, COOR11, SCOR11, OCSR11, COSR11, CSOR11, CN, halogen, or a hydroxyl group; a and b is each 0 to 4; X is oxygen, sulfur, selenium, CR31R32, CO, NR33, or PR34; and R31, R32, R33, and R34 each have the same meaning as R1.

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.