1075724-25-2Relevant academic research and scientific papers
Stereoselective Multicomponent Reactions Using Zincate Nucleophiles: β-Dicarbonyl Synthesis and Functionalization
Murphy, Stephen K.,Zeng, Mingshuo,Herzon, Seth B.
, p. 4880 - 4883 (2016/10/18)
A general strategy for conjugate addition-C-acylation that enables the synthesis of enantioenriched β-dicarbonyl compounds is described. A novel method for derivatizing these adducts by stereo- and site-selective zinc-catalyzed addition of alkyllithium reagents is also reported. These reactions can be performed in tandem to achieve an enantio- and diastereoselective four-component coupling. The in situ generation of weakly basic lithium zincate species is central to the success of all three transformations.
CuH-catalyzed enantioselective intramolecular reductive aldol reactions generating three new contiguous asymmetric stereocenters
Lipshutz, Bruce H.,Amorelli, Benjamin,Unger, John B.
supporting information; experimental part, p. 14378 - 14379 (2009/02/08)
Treatment of β,β-disubstituted-α,β-unsaturated ketones bearing a ketone residue with in situ generated, catalytic CuH ligated by a nonracemic ligand leads to three newly created adjacent chiral centers. Excellent des and ees are obtained for several examples studied. Copyright
