107622-80-0Relevant articles and documents
Cobalt-Catalyzed Hydrogenative Transformation of Nitriles
Zhang, Shaoke,Duan, Ya-Nan,Qian, Yu,Tang, Wenyue,Zhang, Runtong,Wen, Jialin,Zhang, Xumu
, p. 13761 - 13767 (2021/11/17)
Here, we report the transformation of nitrile compounds in a hydrogen atmosphere. Catalyzed by a cobalt/tetraphosphine complex, hydrogenative coupling of unprotected indoles with nitriles proceeds smoothly in a basic medium, yielding C3 alkylated indoles. In addition, the direct hydrogenation of nitriles under the same conditions yielded primary amines. Isotope labeling experiments, along with a series of control experiments, revealed a reaction pathway that involves nucleophilic addition of indoles and 1,4-reduction of a conjugate imine intermediate. Different from reductive alkylation of indoles under an acidic condition, E1cB elimination is believed to occur in this base-promoted hydrogenative coupling reaction.
INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
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Page/Page column 164, (2017/09/02)
The present disclosure is directed to compounds of formula I and methods of their use and preparation, as well as compositions comprising compounds of formula I.
Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5′-amido-5′-deoxyadenosine derivatives
Heidler, Philipp,Zohrabi-Kalantari, Vida,Kaiser, Marcel,Brun, Reto,Emmrich, Thomas,Link, Andreas
body text, p. 1428 - 1436 (2009/08/08)
Given the more or less global spread of multidrug-resistant plasmodia, structurally diverse starting points for the development of chemotherapeutic agents for the treatment of malaria are urgently needed. Thus, a series of 20 adenosine derivatives with a
