1706-12-3

Basic information

• Product Name: 1-METHYL-4-PHENOXY-BENZENE
• Synonyms: 1-METHYL-4-PHENOXY-BENZENE;p-phenoxytoluene;4-Methyldiphenyl ether;4-Methylphenylphenyl ether;Phenyl 4-methylphenyl ether;Phenyl p-tolyl ether;Phenyl(4-methylphenyl) ether
• CAS NO: 1706-12-3
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 184.23378
• EINECS: 216-944-3
• Mol File: 1706-12-3.mol
• Article Data: 164

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 268.8°Cat760mmHg
• Flash Point: 110.6°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 0.0125mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-METHYL-4-PHENOXY-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)
• EPA Substance Registry System: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)

Safety Data

• Hazardous Substances Data: 1706-12-3(Hazardous Substances Data)

Usage

Description

1-METHYL-4-PHENOXY-BENZENE, also known as PMPOB, is a chemical compound characterized by its molecular formula C13H12O. It presents as a colorless to light yellow liquid, which is insoluble in water but readily soluble in organic solvents. PMPOB is recognized for its role as an intermediate in the synthesis of various compounds, including pharmaceuticals and dyes, and serves as a building block in organic synthesis research and development. With its low acute toxicity, PMPOB is not considered a significant environmental or health hazard when managed according to proper safety protocols.

Uses

Used in Pharmaceutical Industry:
1-METHYL-4-PHENOXY-BENZENE is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Dye Industry:
1-METHYL-4-PHENOXY-BENZENE is used as a precursor in the production of dyes, playing a crucial role in the creation of colorants for various applications.
Used in Organic Synthesis Research and Development:
1-METHYL-4-PHENOXY-BENZENE is utilized as a building block in organic synthesis, facilitating the exploration and creation of novel organic compounds for diverse applications.

InChI:InChI=1/C13H12O/c1-11-7-9-13(10-8-11)14-12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 108-86-1 bromobenzene 
• 106-44-5 p-cresol 
• 1192-96-7 potassium p-cresolate 
• 108-90-7 chlorobenzene 
• 624-31-7 4-tolyl iodide 
• 615-37-2 ortho-methylphenyl iodide 
• 108-95-2 phenol 
• 20927-98-4 2-p-tolyloxy-aniline 
• 16308-16-0 1-(diacetoxyiodo)-4-methylbenzene 
• 101-55-3 4-Bromodiphenyl ether 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 98-95-3 nitrobenzene 
• 21218-94-0 methyl 4-phenoxybenzoate 
• 15209-49-1 [di-(4-tolyl)]iodonium tosylate 

Downstream Products

• 106-44-5 p-cresol 
• 3991-61-5 1-methyl-2-phenoxybenzene 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 108-95-2 phenol 
• 54104-82-4 1-p-tolylpyrrolidine 
• 745028-41-5 C₁₁H₁₇N 
• 745028-41-5 C₁₁H₁₇N 
• 745028-41-5 1-(4-methylcyclohexyl)-1H-pyrrole 
• 745028-41-5 1-(4-methylcyclohexyl)-1H-pyrrole 
• 438543-74-9 C₁₃H₁₂O₃ 
• 7320-51-6 2-methyldibenzofuran 

Relevant articles and documents

Oxidation of m-Phenoxytoluene with Ceric Trifluoroacetate

Ceric trifluoroacetate in aqueous trifluoroacetic acid has been found to be especially effective for the oxidation of activated toluenes to the corresponding aldehydes.Ceric ion is consumed in stoichiometric amounts but can be regenerated electrochemically at high current efficiencies (95 percent).A detailed study of the oxidation of m-phenoxytoluene to m-phenoxybenzaldehyde is presented.A study of the reaction mechanism, which involves both cations and radical cations, led to a choise of cosolvents which stabilize these intermediates and thus increase the yield of aldehyde formation.

Synthesis and characterization of nano-cellulose immobilized phenanthroline-copper (I) complex as a recyclable and efficient catalyst for preparation of diaryl ethers, N-aryl amides and N-aryl heterocycles

Functionalized nanocellulose was prepared and employed for immobilization of phenanthroline-copper(I) complex to afford cellulose nanofibril grafted heterogeneous copper catalyst [CNF-phen-Cu(I)]. This nanocatalyst was well characterized using FT-IR, NMR, XRD, CHNS, AAS, TGA, EDX and SEM. The activities of the synthesized catalyst were examined in the synthesis of diaryl ethers via C-O cross-coupling of phenols and aryl iodides, as well as, the preparation of N-aryl amides and N-aryl heterocycles through C-N cross-coupling of amides and N-H heterocycle compounds with aryl halides. In this trend, various substrates containing electron-donating and electron-withdrawing groups were exploited to evaluate the generality of this catalytic protocol. Accordingly, the catalyst demonstrated remarkable catalytic efficiency for both C-N and C-O cross-coupling reactions, thereby resulting in good to excellent yields of the desired products. Furthermore, the recoverability experiments of the catalyst showed that it can be readily retrieved by simple filtration and successfully reused several times with negligible loss of its catalytic activity.

Solvent-free palladium-catalyzed C–O cross-coupling of aryl bromides with phenols

A new solvent-free procedure for C–O cross-coupling between phenols and aryl bromides comprising of Pd2(dba)3/ButBrettPhos catalytic system is efficient for substrates bearing donor or acceptor, as well as bulky substituents.