107624-22-6

Basic information

• Product Name: 2-METHYL-4-(PHENYLMETHOXY)-PYRIDINE
• Synonyms: 2-METHYL-4-(PHENYLMETHOXY)-PYRIDINE;Pyridine, 2-methyl-4-(phenylmethoxy)-
• CAS NO: 107624-22-6
• Molecular Weight: 199.252
• Mol File: 107624-22-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-METHYL-4-(PHENYLMETHOXY)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-(PHENYLMETHOXY)-PYRIDINE(107624-22-6)
• EPA Substance Registry System: 2-METHYL-4-(PHENYLMETHOXY)-PYRIDINE(107624-22-6)

Safety Data

• Hazardous Substances Data: 107624-22-6(Hazardous Substances Data)

Upstream product

• 63071-08-9 4-(benzyloxy)-2-picoline N-oxide 
• 2683-66-1 4-benzyloxypyridine-N-oxide 
• 676-58-4 methylmagnesium chloride 
• 3678-63-5 4-chIoro-2-methylpyridine 
• 100-51-6 benzyl alcohol 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 

Downstream Products

• 618067-34-8 2-[3-(4-fluoro-benzyl)-7-hydroxy-indolizin-1-yl]-2-oxo-N-pyridin-3-yl-acetamide 

Relevant articles and documents

Selective deoxygenation of heteroaromatic N-oxides with olefins catalyzed by ruthenium porphyrin

A new convenient method of deoxygenation of heteroaromatic N-oxides is described. Ruthenium porphyrin was used as a catalyst and this method expressed high yields for o-substituted pyridine N-oxides, quinoline N-oxide derivatives, acridine N-oxide, etc. under mild conditions. Moreover, nitro-, benzyloxy-, and ketone carbonyl groups, which can be affected by the usual deoxygenation methods such as catalytic hydrogenation or borane reduction, were retained.

Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents

Reported herein is an unprecedented base-promoted deborylative alkylation of pyridine N-oxides using 1,1-diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N-oxides and 1,1-diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C?H arylation and methylation of pyridine N-oxides. The reaction also can be applied for the direct introduction of a methyl group to 9-O-methylquinine N-oxide, thus it can serve as a powerful method for late-stage functionalization.

A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

We present a novel series of HIV integrase inhibitors, showing IC50s ranging from 0.01 to over 370 μM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure-activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for designing other novel types of integrase inhibitors.