107673-39-2

Upstream product

• 20566-49-8 ethyl 2-(4-methylbenzyl) acrylate 
• 1367876-24-1 [(Z)-2-methoxycarbonyl-3-(4-methylphenyl)-2-propenyl]triphenylphosphonium bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 115240-91-0 methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate 
• 139413-76-6 methyl (2Z)-2-(bromomethyl)-3-(4-methylphenyl)prop-2-enoate 
• 6619-58-5 diethyl 4-methylbenzylmalonate 
• 21405-60-7 4-methylbenzylmalonic acid 

Downstream Products

• 111510-45-3 2-Benzoylsulfanylmethyl-3-p-tolyl-propionic acid 
• 107673-28-9 (R)-3-Ethylsulfanyl-2-(2-mercaptomethyl-3-p-tolyl-propionylamino)-propionic acid 
• 107688-59-5 (R)-2-(2-Benzoylsulfanylmethyl-3-p-tolyl-propionylamino)-3-ethylsulfanyl-propionic acid 
• 116112-23-3 Sodium; 3-(2-acetylsulfanylmethyl-3-p-tolyl-propionylamino)-benzenesulfonate 
• 116112-22-2 Sodium; 4-(2-acetylsulfanylmethyl-3-p-tolyl-propionylamino)-benzenesulfonate 
• 116155-52-3 Sodium; 3-(2-mercaptomethyl-3-p-tolyl-propionylamino)-benzenesulfonate 
• 116112-21-1 Sodium; 2-(2-acetylsulfanylmethyl-3-p-tolyl-propionylamino)-ethanesulfonate 
• 116112-01-7 Sodium; 4-(2-mercaptomethyl-3-p-tolyl-propionylamino)-benzenesulfonate 
• 116112-00-6 Sodium; 2-(2-mercaptomethyl-3-p-tolyl-propionylamino)-ethanesulfonate 
• 111510-56-6 Thiobenzoic acid S-(2-chlorocarbonyl-3-p-tolyl-propyl) ester 

Relevant academic research and scientific papers

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.

New orally active enkephalinase inhibitors: Their synthesis, biological activity, and analgesic properties

A series of (4s)-4-[(2S)-benzyl-3-mercaptopropionylamino]-4-(N- phenylcarbamoyl)-butyric acids has been identified as potent systemically active enkephalinase inhibitors. Structure-activity relationships (SAR) are discussed. Further chemical modification of the inhibitors was carried out in order to identify the inhibitors which are orally active in an animal model. Compounds of particular interest are the prodrug-like analogues, including 5b (ONO-9902). Their analgesic effects after oral administration were evaluated.