21405-60-7

Upstream product

• 5553-86-6 (4-methylbenzyl)malononitrile 
• 108-88-3 toluene 
• 104-81-4 4-Methylbenzyl bromide 
• 6619-58-5 diethyl 4-methylbenzylmalonate 
• 104-82-5 4-Methylbenzyl chloride 

Downstream Products

• 107688-59-5 (R)-2-(2-Benzoylsulfanylmethyl-3-p-tolyl-propionylamino)-3-ethylsulfanyl-propionic acid 
• 107673-28-9 (R)-3-Ethylsulfanyl-2-(2-mercaptomethyl-3-p-tolyl-propionylamino)-propionic acid 
• 111510-45-3 2-Benzoylsulfanylmethyl-3-p-tolyl-propionic acid 
• 111510-56-6 Thiobenzoic acid S-(2-chlorocarbonyl-3-p-tolyl-propyl) ester 
• 107673-39-2 2-(4-Methyl-benzyl)-acrylic acid 
• 240801-32-5 vinyl 3-(4-methylphenyl)propanoate 
• 1505-50-6 3-(4-Methylphenyl)propanoic acid 

Relevant academic research and scientific papers

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

The effect of vinyl esters on the enantioselectivity of the lipase-catalysed transesterification of alcohols

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol 1 was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alcohol was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, respectively. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalysed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of 1 was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-1 and then the enantioselective hydrolysis of the resultant ester to afford (S)-1.