107685-90-5

Upstream product

• 87568-69-2 (+/-)-1-(hydroxy(((p-nitrobenzyl)oxy)carbonyl)methyl)-4(R*)-(2,2-dimethoxyethyl)-3(R*)-(1(S*)-((((p-nitrobenzyl)oxy)carbonyl)oxy)ethyl)azetidin-2-one 
• 77447-98-4 (+/-)-4β-(2,2-dimethoxyethyl)-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one 
• 64370-35-0 p-nitrobenzyl glyoxylate 
• 87568-66-9 {(2R,3R)-2-(2,2-Dimethoxy-ethyl)-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 

Downstream Products

• 87568-67-0 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-1-carba-2-penem-3-carboxylate 
• 87568-68-1 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-2-(phenylthio)-1-carbapenam-3-carboxylate 
• 87638-51-5 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-2-(phenylthio)-1-carbapenam-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of β-lactam antibiotics by the sulfeno-cycloamination

A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.