77447-98-4

Upstream product

• 72447-81-5 3-Nitropropanal dimethyl acetal 
• 72447-85-9 cis-3-(1'R^*-hydroxyethyl-4-(2',2'-dimethoxyethyl))-2-azetidinone 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 81038-18-8 3,3-Dimethoxy-propionitrile N-oxide 
• 72447-85-9 trans-4-<(2',2'-dimethoxy)ethyl>-3-<(1'R)-hydroxyethyl>azetidin-2-one 
• 76855-55-5 methyl 3-methyl-2-[(3S,4R)-4-methylthio-3-{(1S)-1-(p-nitrobenzyloxycarbonyloxy)ethyl}-2-oxoazetidin-1-yl]-but-2-enoate 
• 80559-16-6 methyl 2-[(3S,4S)-4-chloro-3-{(1S)-1-(p-nitrobenzyloxycarbonyloxy)ethyl}-2-oxoazetidin-1-yl]-3-methylbut-2-enoate 
• 74614-77-0 (3S,4R)-3-(1-hidroxyethyl)-1-(1-methoxycarbonyl-2-methyl-1-propenyl)-4-methylthio-2-azetidinone 
• 67-56-1 methanol 
• 80527-88-4 methyl 3-methyl-2-[(3S,4R)-3-{(1S)-1-(p-nitrobenzyloxycarbonyloxy)ethyl}-2-oxo-4-allylazetidin-1-yl]but-2-enoate 
• 72447-84-8 methyl 3-amino-5-hydroxy-1,1-dimethoxyhexane-4-carboxylate 
• 72447-82-6 trans-4-methoxycarbonyl-3-(2',2'-dimethoxyethyl)-5-methylisoxazoline 
• 73844-78-7 trans-3-(2',2'-dimethoxyethyl)-5-methylisoxazoline-4-carboxylic acid 
• 78522-77-7 (S)-3-Amino-2-((R)-1-hydroxy-ethyl)-5,5-dimethoxy-pentanoic acid 

Downstream Products

• 73844-79-8 (+/-)-4β-(2',2'-trimethylenedithioethyl)-3α-((1'-S*)-p-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone 
• 65991-26-6 p-nitrobenzyl (+/-)-cis-3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 78072-35-2 p-nitrobenzyl (+/-)-cis-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-3-phenylthio-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 98243-79-9 sodium (+/-)-cis-6β-<(1S^*)-1-hydroxyethyl>-7-oxo-3-phenylthio-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 87568-68-1 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-2-(phenylthio)-1-carbapenam-3-carboxylate 
• 87638-51-5 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-2-(phenylthio)-1-carbapenam-3-carboxylate 
• 87568-66-9 {(2R,3R)-2-(2,2-Dimethoxy-ethyl)-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 107685-90-5 [(3R,4R)-3-[(S)-1-(4-Nitro-benzyloxycarbonyloxy)-ethyl]-2-oxo-4-(2-oxo-ethyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 87568-64-7 (+/-)-3(R*)-(1(S*)-((((p-nitrobenzyl)oxy)carbonyl)oxy)ethyl)-4(R*)-(3-(((p-nitrobenzyl)oxy)carbonyl)-3-chloro-2-(phenylthio)propyl)azetidin-2-one 
• 87568-65-8 (+/-)-3(R*)-(1(S*)-((((p-nitrobenzyl)oxy)carbonyl)oxy)ethyl)-4(R*)-(3-(((p-nitrobenzyl)oxy)carbonyl)-2-chloro-3-(phenylthio)propyl)azetidin-2-one 
• 87568-67-0 (+/-)-p-nitrobenzyl 6(R*)-(1(S*)-((((p-nitronbenzyl)oxy)carbonyl)oxy)ethyl)-1-carba-2-penem-3-carboxylate 
• 87568-62-5 (+/-)-3(R*)-(1(S*)((((p-nitrobenzyl)oxy)carbonyl)oxy)ethyl)-4(R*)-(3-(((p-nitrobenzyl)oxy)carbonyl)-2-propenyl)azetidin-2-one 
• 76347-45-0 (+/-)-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4β-(3-p-nitrobenzyloxycarbonyl-2-oxopropyl)azetidin-2-one 
• 76335-78-9 p-nitrobenzyl (+/-)-cis-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-3,7-dioxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 

Relevant academic research and scientific papers

STEREO- AND REGIOSPECIFIC ALLYLATION OF 4-CHLOROAZETIDINONES WITH ALLYLSILANES: CONVERGENT SYNTHESIS OF A KEY INTERMEDIATE FOR (+)-THIENAMYCIN

An efficient stereospecific synthesis of optically active 4-allylazetidinones (6, 7, 11, and 15a,b) has been accomplished using silver-promoted coupling reaction of allylsilanes (5 and 14b) with 4-chloroazetidinones (3, 4, and 10a,b) derived from penicillins.

Total Synthesis of (+/-)-Epithienamycins A and B and Derivatives

(+/-)-(3R*,4R*)-4-(2,2-Dimethoxyethyl)-3-*)-1-hydroxyethyl>azetidin-2-one (7), which has been stereoselectively synthesised via the 4-methoxycarbonylisoxazoline (4), was converted into (+/-)-epithienamycins A (2) and B

Studies on the Syntheses of Heterocyclic Compounds. 800. A Formal Total Synthesis of (+/-)-Thienamycin and (+/-)-Decysteaminylthienamycin Derivative

The synthesis of a key intermediate for the preparation of (+/-)-thienamycin (1) and its derivatives has been developed.By 1,3-dipolar cycloaddition, the nitrile oxide derived from 3-nitropropanal dimethyl acetal (3) was added to methyl crotonate to give