58022-65-4

Usage

Uses

Used in Organic Synthesis:
2-Methyl-5-(pyridin-4-yl)-1,3,4-oxadiazole is used as a building block in organic synthesis for the creation of various organic compounds. Its unique structure allows it to be a versatile component in the formation of complex molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-Methyl-5-(pyridin-4-yl)-1,3,4-oxadiazole is utilized for its potential biological activities. It serves as a valuable scaffold in the development of new drug candidates, contributing to the advancement of medicinal chemistry.
Used in Medicinal Chemistry:
2-Methyl-5-(pyridin-4-yl)-1,3,4-oxadiazole is applied in medicinal chemistry as a scaffold for designing and developing innovative pharmaceutical agents. Its incorporation into drug molecules can potentially enhance their therapeutic properties and efficacy.

Upstream product

• 54-85-3 isoniazid 
• 1078-38-2 N-acetyl-N'-isonicotinoylhydrazine 
• 14777-27-6 methyl acetimidate hydrochloride 
• 14389-12-9 5-(4-pyridyl)tetrazole 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 78-39-7 Triethyl orthoacetate 
• 14389-12-9 4-(1H-tetrazol-5-yl)-pyridine 
• 75-36-5 acetyl chloride 

Downstream Products

• 1173072-77-9 1-amino-4-(5-methyl-1,3,4-oxadiazol-2-yl)pyridinium mesitylene sulfonate 
• 1208535-68-5 3-(3-methyl-5-(pyridin-4-yl)-1,2,4-triazol-4-yl)benzoic acid 
• 1208535-67-4 4-(3-methyl-5-(pyridin-4-yl)-1,2,4-triazol-4-yl)benzoic acid 
• 1352638-29-9 5-(3-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl) isophthalic acid 

Relevant academic research and scientific papers

Syntheses, structural diversities and characterization of a series of coordination polymers with two isomeric oxadiazol-pyridine ligands

In this work two positional-isomeric oxadiazol-pyridine ligands 3-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine (L1) and 4-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine (L2) have been designed and synthesized. A series of novel coordination polymers, namely [Cd2(μ2-L1)2(μ2-NCS)4]n (1), {[Cd(L1)(μ2-dca)2(H2O)]·H2O}n (2), {[Cu(μ2-L1)2(NCS)2]·0.5H2O}n (3), {[Ag2(μ2-L1)(μ3-L1)2]·2PF6}n (4), {[Ag3(μ2-L1)4(μ2-CF3SO3)(CF3SO3)]·CF3SO3} (5), {[Cd(L2)2(μ2-NCS)2]}n (6), [Ag(μ2-L2)(μ2-CF3SO3)]n (7) and {[Ag(μ2-L2)]·BF4}n (8) have been isolated. Both 1 and 2 are 2D CdII coordination polymers containing infinite {Cd-NCS-Cd} chains (for 1) or infinite {Cd-dca-Cd} layers (for 2), respectively. 3 is a 2D CuII coordination polymer, in which central metal ions are bridged via a bidentate bridging L1 ligand. While when different AgI salts were introduced into the reaction system, 1D AgI coordination polymers 4 and 5 with diverse coordination modes can be isolated. Furthermore, when the isomeric oxadiazol-pyridine L2 is used to replace L1 in the reaction system, 6-8 can be isolated. 6 is a 2D CdII coordination polymer containing {Cd-NCS-Cd} layers. 7 is a 2D neutral AgI coordination polymer while 8 is a 2D cationic AgI coordination polymer. Variable temperature magnetic susceptibility measurements (2-300 K) reveal anti-ferromagnetic interactions between central copper(ii) ions for 3. Solid-state luminescent properties of 1, 2 and 4-8 have been investigated indicating strong fluorescent emissions. Additionally, luminescent measurements illustrate that complex 8 exhibits highly sensitive luminescence sensing for Cr2O72? ions in aqueous solutions with high quenching efficiency Ksv = 2.08 × 104 L mol?1 and low detection limit (0.19 μM (S/N = 3)). 8 also represents the first report of a coordination polymer based on oxadiazol-pyridine derivatives with a luminescence response to Cr2O72? anion pollutants in aqueous solutions.

Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides

Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-l

Fluoroboric acid-Ag (I) coordination compound constructed based on 4-(5-methyl-1,3,4-oxadiazole)pyridine ligand, and synthesis method thereof

The invention discloses a fluoroboric acid-Ag (I) coordination compound constructed based on a 4-(5-methyl-1,3,4-oxadiazole)pyridine ligand, and a synthesis method thereof. According to the present invention, the fluoroboric acid-Ag (I) coordination compound having a two-dimensional structure and using the 4-(5-methyl-1,3,4-oxadiazole)pyridine ligand is synthesized by using monovalent silver ionsAgBF4 as a main body, can adsorb a variety of dyes, and has application potential.

Thiocyanate-Cd(II) coordination compound built by 4-(5-methyl-1, 3, 4-oxadiazole)pyridine and synthesizing method of thiocyanate-Cd(II) coordination compound

The invention discloses a thiocyanate-Cd(II) coordination compound built by 4-(5-methyl-1, 3, 4-oxadiazole)pyridine and synthesizing method of the thiocyanate-Cd(II) coordination compound. The generalchemical formula of the coordination compound is [Cd2(L)2(NCS)4]. The synthesizing method includes: weighing CdBr2, NH4NCS and the 4-(5-methyl-1, 3, 4-oxadiazole)pyridine serving as the ligand, evenly mixing to perform reaction, and cooling to room temperature to obtain colorless and transparent crystals, namely the thiocyanate-Cd(II) coordination compound. Test results show that the thiocyanate-Cd(II) coordination compound has a good adsorption/removing effect on various dye in water environments.

Trifluoromethanesulfonic acid-Ag (I) coordination compound constructed with 4-(5-methyl-1,3,4-oxadiazole)pyridine, and synthesis method thereof

The invention discloses a trifluoromethanesulfonic acid-Ag (I) coordination compound constructed based on 4-(5-methyl-1,3,4-oxadiazole)pyridine, and a synthesis method thereof. According to the present invention, the trifluoromethanesulfonic acid-Ag (I) coordination compound having a two-dimensional structure and using a 4-(5-methyl-1,3,4-oxadiazole)pyridine ligand is synthesized by using the monovalent silver ions AgCF3SO3 as the main body and using 4-(5-methyl-1,3,4-oxadiazole)pyridine as the ligand; and the trifluoromethanesulfonic acid-Ag (I) coordination compound can adsorb a variety of dyes, and has application potential.

Applications of 4-(5-methyl-1,3,4-oxadiazole)pyridine-based trifluoromethanesulfonic acid-Ag (I) coordination compound in adsorption of dyes

The invention discloses applications of a 4-(5-methyl-1,3,4-oxadiazole)pyridine-based trifluoromethanesulfonic acid-Ag (I) coordination compound in adsorption of dyes. According to the present invention, the 4-(5-methyl-1,3,4-oxadiazole)pyridine-based trifluoromethanesulfonic acid-Ag (I) coordination compound with a two-dimensional structure is synthesized by using monovalent silver ions AgCF3SO3as a main body and using 4-(5-methyl-1,3,4-oxadiazole)pyridine as a ligand, can adsorb a variety of dyes, and has application potential.

Achieving High 1H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds

Despite the successful use of isoniazid, rifampicin, pyrazinamide and ethambutol in the treatment of tuberculosis (TB), it is a disease of growing global concern. We illustrate here a series of methods that will dramatically improve the magnetic resonance imaging (MRI) detectability of nineteen TB-relevant agents. We note that the future probing of their uptake and distribution in vivo would be expected to significantly enhance their efficacy in disease treatment. This improvement in detectability is achieved by use of the parahydrogen based SABRE protocol in conjunction with the 2H-labelling of key sites within their molecular structures and the 2H-labelling of the magnetization transfer catalyst. The T1 relaxation times and polarization levels of these agents are quantified under test conditions to produce a protocol to identify structurally optimized motifs for future detection. For example, deuteration of the 6-position of a pyrazinamide analogue leads to a structural form that exhibits T1 values of 144.5 s for 5-H with up to 20 % polarization. This represents a >7-fold extension in relaxation time and almost 10-fold improvement in polarization level when compared to its unoptimized structure.

A microporous copper metal-organic framework with high H2 and CO2 adsorption capacity at ambient pressure

Fully accessible: Uptakes of 9.2 mmol g-1 (40.5 wt %) for CO2 at 273 K/0.1 MPa and 15.23 mmol g-1 (3.07 wt %) for H2 at 77 K/0.1 MPa are among the highest reported for metal-organic frameworks (MOFs) and are fou

Highly functionalised 3,4,5-trisubstituted 1,2,4-triazoles for future use as ligands in coordination polymers

An optimised synthesis of 3,4,5-trisubstituted 1,2,4-triazoles, that can be used as linkers for metal organic frameworks (MOFs), is described. The substituents in 3- and 5-position of the triazole have a significant impact on the torsion angles between the aromatic rings and therefore influence on solubility and coordination behaviour of these ligands.

Synthesis of substituted N-[4(5-Methyl/phenyl-1,3,4-oxadiazol-2- Yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene sulfonamides as anti-inflammatory and anti-cancer agents

Fourteen novel substituted N-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6- dihydropyridin-1(2H)-yl] benzamide/benzene sulfonamides (11a-n) were synthesized in fair to good yields via sodium borohy-dride reduction of the corresponding substituted N-(benzoylimino)-4-(5-methyl/5-phenyl-1,3,4-oxadia- zol-2yl) pyridinium ylide (10a-n) in absolute ethanol.