59618-44-9

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-METHYLPHENYL)-4-OXOBUTYRIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structure of different drugs.
Used in Organic Compounds Synthesis:
4-(3-METHYLPHENYL)-4-OXOBUTYRIC ACID is used as a building block in the production of other organic chemicals, contributing to the formation of complex molecules and compounds.
Used in Chemical Research:
4-(3-METHYLPHENYL)-4-OXOBUTYRIC ACID is utilized in chemical research for studying the properties and reactions of aromatic ketones and their derivatives, furthering the understanding of organic chemistry and its applications.

InChI:InChI=1/C11H12O3/c1-8-3-2-4-9(7-8)10(12)5-6-11(13)14/h2-4,7H,5-6H2,1H3,(H,13,14)

Upstream product

• 84498-32-8 3-oxo-3-m-tolyl-1-cyanopropane 
• 118540-56-0 4-(3-methylphenyl)-4-oxo-2-butenoic Acid 
• 1711-06-4 3-Methylbenzoyl chloride 
• 84498-31-7 3-dimethylamino-m-methylpropiophenone hydrochloride 
• 108-30-5 succinic acid anhydride 
• 591-17-3 meta-bromotoluene 
• 28987-79-3 m-tolylmagnesium bromide 
• 108-88-3 toluene 
• 106-44-5 p-cresol 
• 585-74-0 3-Methylacetophenone 
• 620-23-5 m-tolyl aldehyde 
• 24165-64-8 1-(3-methylphenyl)but-3-en-1-ol 
• 502610-58-4 1-(3-methylphenyl)-1,4-butanediol 
• 160723-51-3 methyl 4-oxo-4-(m-tolyl)butanoate 

Downstream Products

• 22156-45-2 4-(m-tolyl)butanoic acid 
• 57494-18-5 4-isopropyl-4-m-tolyl-γ-butyrolactone 
• 117809-02-6 4-acetylthio-3-(3-methylbenzoyl)butyric acid 
• 51015-29-3 6-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 59618-42-7 5-hydroxy-1-methyl-5-(m-tolyl)pyrrolidin-2-one 
• 6939-35-1 5-methyl-1-tetralone 
• 5462-81-7 7-methyl-3,4-dihydronaphthalen-1(2H)-one oxime 
• 22009-37-6 7-methyl-3,4-dihydro-2H-naphthalen-1-one 
• 1079-72-7 6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 1427435-36-6 7-(4-methylphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-thione 

Relevant academic research and scientific papers

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters

Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification. This strategy is capable of constructing enantioenriched lactams and benzo-lactams of a five-, six-, or seven-membered ring in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodology.

TMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide

Numerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. T

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

One-pot synthesis of tetralin derivatives from 3-benzoylpropionic acids: Indium-catalyzed hydrosilylation of ketones and carboxylic acids and intramolecular cyclization

This reducing system was composed of a small amount (1 mol%) of In(OAc)3, Me2PhSiH, and I2 that effectively catalyzed the hydrosilylation of two different carbonyl groups, a ketone and a carboxylic acid found in 3-benzoylpropionic acids, followed by a subsequent intramolecular cyclization that led to the one-pot preparation of tetralin derivatives.

Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives

Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3, 5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs.

A practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, an antirheumatic agent (part 1).

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel-Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in 63% yield without silica gel column purification. Compound 1 was prepared by Michael addition of 2 with thioacetic acid (4) in 74% yield. Overall, 1 was obtained in 47% yield from 3. The structures and synthetic mechanisms of by-products (five compounds) of 2 were also clarified.

Biogenetic-type Synthesis of Sesquichamaenol

A hypothetical biosynthetic pathway for the conversion of farnesylpyrophosphate into seaquichamaenol 1, a modified sesquiterpenoid isolated from Chaemaecyparis formosensis Matsum is proposed. The synthesis of 1 which lends experimental support to the prop

Ion triggered alkylation of biological targets by silyloxy aromatic agents

A silyloxy aromatic derivative capable of alkylating a target biological molecule when activated by ionic strength. A sequence directed reagent may be constructed by conjugating a methyl silyloxy aromatic derivative to a hexamethylamino linker attached to either the 5' or 3' terminus of an oligonucleotide. Annealing this modified fragment of DNA to its complementary sequence allows for target modification subsequent to ionic activation. The product of this reaction is a covalent crosslink between the reagent and target strands resulting from an alkylation of DNA by the activated silyloxy aromatic derivative. In a preferred embodiment, a nitrophenyl or bromo group is attached to a methyl group of the silyloxy aromatic derivative. This reagent may be similarly linked to an oligonucleotide probe. Activation of the alkylating agent by an ionic signal (X) which may naturally occur, or may be introduced into the media containing the target molecule, such as by the introduction of a salt (MX).

Ion triggered alkylation of biological targets by silyloxy aromatic agents

A silyloxy aromatic derivative capable of alkylating a target biological molecule when activated by ionic strength. A sequence directed reagent may be constructed by conjugating a methyl silyloxy aromatic derivative to a hexamethyiamino linker attached to either the 5' or 3' terminus of an oligonucleotide. Annealing this modified fragment of DNA to its complementary sequence allows for target modification subsequent to ionic activation. The product of this reaction is a covalent crosslink between the reagent and target strands resulting from an alkylation of DNA by the activated silyloxy aromatic derivative. In a preferred embodiment, a nitrophenyl or bromo group is attached to a methyl group of the silyloxy aromatic derivative. This reagent may be similarly linked to an oligonucleotide probe. Activation of the alkylating agent by an ionic signal (X) which may naturally occur, or may be introduced into the media containing the target molecule, such as by the introduction of a salt (MX).