107933-56-2Relevant academic research and scientific papers
One-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles
Roh, Jaroslav,Vávrová, Kate?ina,Hrabálek, Alexandr
experimental part, p. 1411 - 1414 (2010/04/25)
The one-pot regioselective preparation of 5-aryl/alkyl-2-vinyl-2H-tetrazoles from 5-substituted tetrazoles via a very simple procedure using 1,2-dibromoethane and triethylamine without the need of any catalyst is described. The mechanism of this reaction is also discussed.
Synthesis of 3-Phenylpyrazoles from 2-Alkenyl-5-phenyltetrazoles
Moody, Christopher J.,Rees, Charles W.,Young, Richard G.
, p. 329 - 333 (2007/10/02)
2-Alkenyl-5-phenyltetrazoles 7a-e are readily converted by thermolysis or photolysis into 3-phenylpyrazoles 11a-e in good to excellent yield (Table 2).The alkenyltetrazoles 7 are prepared by direct or indirect dehydration of the alcohols 5 formed by quenching α-lithioalkyltetrazoles with aldehydes.
SYNTHESIS OF FUNCTIONALLY SUBSTITUTED N-VINYLTETRAZOLES
Vereshchagin, L. I.,Buzilova, S. R.,Mityukova, T. K.,Proidakov, A. G.,Kizhnyaev, V. N.,et al.
, p. 1777 - 1783 (2007/10/02)
5-Alkyl- and 5-aryl-N-vinyltetrazoles (II) are formed during vinyl exchange between 5-substituted tetrazoles (I) and vinyl acetate in the presence of the copper acetate-boron trifluoride etherate catalytic system.The direction of vinylation depends on steric effects and on the electronic nature of the substituents at position 5 of the tetrazole ring.A series of functionally substituted 2-vinyltetrazoles were obtained by nucleophilic substitution of the chlorine in 2-vinyl-5-chloromethyltetrazole.
