107947-26-2

Basic information

• Product Name: C₁₄H₁₃NO₂
• CAS NO: 107947-26-2
• Molecular Weight: 227.263
• Mol File: 107947-26-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₃NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₃NO₂(107947-26-2)
• EPA Substance Registry System: C₁₄H₁₃NO₂(107947-26-2)

Safety Data

• Hazardous Substances Data: 107947-26-2(Hazardous Substances Data)

Upstream product

• 134-92-9 4-hydroxy-4'-methylbenzophenone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 108-88-3 toluene 

Downstream Products

• 1255773-91-1 C₂₁H₂₅NO₅ 
• 1255774-49-2 C₁₄H₁₅NO*ClH 
• 1255774-50-5 C₁₉H₂₃NO₃ 

Relevant articles and documents

Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis

Well-characterized resins of high purity are critical for effective solid phase peptide synthesis (SPPS). The quality of commercial (4-methyl)benzhydrylamine-resin (MBHA-resin), used for the synthesis of peptide amides, is not consistent and residual ketone functionalities are frequently present. Such ketone or aldehyde impurities lead to the formation of acylation-resistant deletion peptides in SPPS. To avoid these undesirable side reactions, we have optimized the preparation of two amide-generating linkers, which, in combination with aminomethyl-resin prepared directly from polystyrene resin, serve as alternatives to MBHA-resin for peptide amide synthesis. Then we have explored their comparative properties in SPPS. Use of sonication in reductive amination facilitated the synthesis of both benzhydrylamine (BHA) and MBHA linkers. We have optimized the preparation of two amide-generating linkers for use in stepwise solid phase peptide synthesis. In combination with aminomethyl-resin prepared directly from polystyrene resin, these linkers serve as alternatives to MBHA-resin for peptide amide synthesis. Copyright