107959-97-7

Upstream product

• 922-69-0 1,1-dimethoxyethylene 
• 107941-43-5 methyl 6-ethyl-4-<<5-methoxy-1-(phenylmethoxy)-2-naphthyl>methyl>-2-oxo-2H-pyran-5-carboxylate 
• 71186-94-2 2-bromo-5-methoxynapththalen-1-ol 
• 107941-42-4 methyl 4-<5-methoxy-1-(phenylmethoxy)-2-naphthyl>-2-butynoate 
• 107959-96-6 5-methoxy-1-(phenylmethoxy)-2-<3-(trimethylsilyl)-2-propynyl>naphthalene 
• 107941-41-3 5-methoxy-1-(phenylmethoxy)-2-(2-propynyl)naphthalene 
• 3588-80-5 5-methoxynaphthalen-1-ol 
• 107941-39-9 2-bromo-5-methoxy-1-(phenylmethoxy)naphthalene 

Relevant academic research and scientific papers

Synthetic Approach to Aklavinone Using 2-Oxo-2H-pyran-5-carboxylate (Coumalate) Intermediates

A novel approach for the preparation of aklavinone 5 is described in which the key step is the cycloaddition of a substituted coumalate with a ketene acetal to produce a masked A ring with the C and D rings attached.The 4-(arylmethyl)coumalate 53 was prepared from naphthalene-1,5-diol (6) by a seven step route involving as the key step the cyclocondensation of the methyl (arylmethyl)propiolate 52 with methyl 3-oxopentanoate 10.Cycloaddition of 53 with dimethyl ketene acetal 12 produced the potential A-ring precursor 67, which could not be cleanly reduced, thereby ending this scheme.The preparation of functionalized 4,6-dialkylpyrone-5-carboxylates and their use in the synthesis of bicyclic lactones and substituted benzoates via cycloaddition reactions are also described.