107969-75-5

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 59749-96-1 3-amino-3-thioxo-N-phenylpropanamide 
• 62037-06-3 1-chloro-4-(dibromomethyl)benzene 
• 613-89-8 2-Aminoacetophenone 
• 26090-73-3 p-Chlorbenzaldehyd-acethydrazon 
• 24721-26-4 4-chlorochalcone 
• 82572-06-3 P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide 

Downstream Products

• 1498-82-4 4-(4'-chlorophenyl)-2,6-diphenylpyridine 
• 1146299-83-3 4-(4-chlorophenyl)-1,2-diphenylcyclopentane-1,2-diol 
• 135765-29-6 4-(4-chlorophenyl)-2,6-diphenyl-(4H)-pyran-3,5-dicarbaldehyde 

Relevant academic research and scientific papers

Highly Chemoselective Solvent-Free Synthesis of 1,3,5-Triaryl-1,5-diketones: Crystallographic Investigation and Intramolecular Weak Bifurcated H Bonds Involving Aliphatic C-H Group

Several 1,3,5-triaryl-1,5-diketones have been chemoselectively synthesized under solvent-free conditions. It was found that intramolecular weak bifurcated H-bonds interaction of aliphatic C-H group plays a decisive role in the structural arrangement of 3-

In situ formed acetals facilitated direct Michael addition of unactivated ketones

TfOH-promoted synthesis of 1,5-diketones by the Michael reaction of unactivated ketones with chalcones has been described. Acetals formed under HC(OMe)3/TfOH conditions generate the required enol-equivalents for a smooth Michael reaction. A wide array of symmetrical and unsymmetrical 1,5-diketones has been synthesised.

Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives

The porcine pancreas lipase (PPL) type II catalyzes the aminolysis of benzylidene malonates by regiospecific amidation of substrates and afforded the Z-isomer; no E-isomer or diamide byproducts were observed. PPL also catalyzes Michael addition of acetophenone to various derivatives of chalcones.

Synthesizing method for diketone compound

The invention relates to a synthesizing method for a diketone compound shown in the formula (III).The method comprises the steps that under a nitrogen atmosphere with a catalyst, an assistant and alkali, a compound shown in the formula (I) and a compound shown in the formula (II) are added into an organic solvent for a reaction, posttreatment is carried out after the reaction is finished, and thus the compound shown in the formula (III) is obtained, wherein R1 is selected from H or C1-C6 alkyl or C1-C6 alkoxy or halogen, R2 is selected from H or C1-C6 alkyl or C1-C6 alkoxy, and X is halogen.According to the method, the composite reaction system composed of a unique reaction substrate, the catalyst, the assistant, alkali and the organic solvent is adopted, the reaction among the materials is effectively promoted through the synthetic action of the system, convention of the materials to the product is promoted, the target product can be obtained at a high yield, and wide market prospects are achieved.

Copper-catalyzed synthesis of 1,3,5-triarylpentane-1,5-diones from α,β-unsaturated ketones

An efficient method for copper catalyzed synthesis of 1,3,5-triarylpentane-1,5-diones using α,β-unsaturated ketones as unique starting materials is described. The protocol offers several advantages such as simple, inexpensive reagents, mild reaction condi

Unexpected synthesis of 1,3,5-triarly-1,5-diketones from aryl ketones via di-enamine mechanism

An unexpected reaction of aryl ketone with acetohydrazone of aromatic aldehyde via 1,2-di-enamine/di-iminium mechanism was discovered, leading to efficient synthesis of 1,3,5-triaryl-1,5-diketones in good to excellent yields.

Unusual Michael reaction of 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one with 3-amino-N-phenyl-3-thioxopropanamide

3-(4-Chlorophenyl)-1-phenylprop-2-en-1-one reacted with 3-amino-N-phenyl-3-thioxopropanamide under basic conditions in ethanol to give a mixture of 3-(4-chlorophenyl)-2-cyano-5-oxo-N,5-diphenylpentanamide and 3-(4-chlorophenyl)-1,5-diphenylpentane-1,5-dione. The structure of the former was determined by X-ray analysis. The reaction of the same compounds in DMSO in the presence of sodium hydroxide produced 4-(4-chlorophenyl)-N,6-diphenyl-2- thioxo-1,2,3,4-tetrahydropyridine-3-carboxamide.

Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN

A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of diketoximes using sodium cyanoborohydride is described.

A Novel Formation of Phenyl-Substituted Pyridines by the Reaction of N-(Diphenylphosphinyl)-1-azaallyl Anions with α,β-Unsaturated Carbonyl Compounds. A New Synthetic Equivalent of Primary Vinylamines

The N-phosphinyl-1-azaallyl anions, which were derived from the corresponding imine or enamine reacted with α,β-unsaturated carbonyl compounds to afford phenyl-substituted pyridines along with 1-propanone and 1,5-pentanedione derivatives.A plausible mechanism involving a sequence of Michael addition and intramolecular aza-Horner-Wittig reaction is described, and the 1-azaallyl anions were found to behave as a synthetic equivalent of primary vinylamines.