107986-49-2

Basic information

• Product Name: 2-Acetamido-4-bromophenol
• Synonyms: 2-Acetamido-4-bromophenol;N-(5-Bromo-2-hydroxyphenyl)acetamide;N-Acetyl 5-bromo-2-hydroxyaniline
• CAS NO: 107986-49-2
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 107986-49-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Acetamido-4-bromophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetamido-4-bromophenol(107986-49-2)
• EPA Substance Registry System: 2-Acetamido-4-bromophenol(107986-49-2)

Safety Data

• Hazardous Substances Data: 107986-49-2(Hazardous Substances Data)

Usage

General Description

2-Acetamido-4-bromophenol is a chemical compound with the molecular formula C8H8BrNO2. It is a pale yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic materials. 2-Acetamido-4-bromophenol contains both an acetamido group and a bromophenol group, making it useful in a variety of chemical reactions. It is known for its antimicrobial properties and is often used in the production of antifungal and antibacterial agents. Additionally, it is used in the synthesis of dyes and as a reagent in organic chemistry reactions. Overall, 2-Acetamido-4-bromophenol is a versatile chemical with various industrial applications.

Upstream product

• 110-86-1 pyridine 
• 861008-59-5 2-benzylidenamino-4-bromo-phenol 
• 108-24-7 acetic anhydride 
• 2163-77-1 3-amino-4-hydroxyphenylarsonic acid 
• 40925-68-6 2-amino-4-bromo-phenol 
• 123-54-6 acetylacetone 
• 614-80-2 2-(acetylamino)phenol 
• 95-55-6 2-amino-phenol 
• 65440-82-6 O-(4-bromophenyl)hydroxylamine 
• 328081-49-8 (p-bromo-N-phenoxy)phthalimide 
• 5467-74-3 4-Bromophenylboronic acid 
• 75-36-5 acetyl chloride 
• 7693-52-9 4-bromo-2-nitrophenol 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 105655-01-4 6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine 
• 1053733-51-9 (3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-2,2-dimethyl-4,8-bis-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one 
• 88301-40-0 N-(5-bromo-2-methoxyphenyl)acetamide 
• 1256360-26-5 N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide 
• 24036-48-4 2-chloro-N-(5-bromo-2-hydroxyphenyl)acetamide 
• 40925-68-6 2-amino-4-bromo-phenol 
• 70977-85-4 1-(2-hydroxy-3-amino-5-bromophenyl)ethan-1-one 

Relevant articles and documents

Mild and Regioselective Bromination of Phenols with TMSBr

In this work, an unexpected promoting effect of by-product thioether was observed, leading to a mild and regioselective bromination of phenols with TMSBr. This method can tolerate a series of functional groups such as the reactive methoxyl, amide, fluoro, chloro, bromo, aldehyde, ketone and ester groups, and has the potential to recycle the by-product thioether and isolate the desired product under column chromatography-free conditions. Mechanism studies revealed that O–H···S hydrogen bond may be formed between phenol and by-product thioether. Possibly owing to the steric hindrance effect from by-product thioether, the electrophilic bromination at para-position of phenols is much favorable.

INHIBITORS OF CBL-B AND METHODS OF USE THEREOF

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

Cp?Rh(III)/Bicyclic Olefin Cocatalyzed C-H Bond Amidation by Intramolecular Amide Transfer

A bicyclic olefin was discovered as a cocatalyst in a Cp?Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling partner for the C-H amidation. This methodology was successfully applied to the late-stage diversification of natural products and a marketed drug under mild conditions.