108008-06-6

Basic information

• Product Name: 1,2-Propanediol, 3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (R)-
• CAS NO: 108008-06-6
• Molecular Formula: C15H22O4
• Molecular Weight: 266.337
• Mol File: 108008-06-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (R)-(108008-06-6)
• EPA Substance Registry System: 1,2-Propanediol, 3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-, (R)-(108008-06-6)

Safety Data

• Hazardous Substances Data: 108008-06-6(Hazardous Substances Data)

Upstream product

• 56441-69-1 2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 63659-15-4 1-benzyloxy-4-(2-cyclopropylmethoxyethyl)benzene 
• 63659-16-5 4-[2-(cyclopropylmethoxy)-ethyl]-phenol 
• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 
• 108008-05-5 (R)-(+)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol acetonide 

Downstream Products

• 91878-53-4 (+)-Betaxolol 
• 108008-08-8 (R)-4-<2-(cyclopropylmethoxy)ethyl>phenyl 2,3-epoxypropyl ether 

Relevant articles and documents

A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution

Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.