108159-96-2

Usage

Uses

Used in Pharmaceutical Industry:
3-fluoro-5-nitrobenzaldehyde is used as a reactant for the design and synthesis of selective activators of cardiac myosin. These activators play a crucial role in enhancing the contractile function of the heart, which can be beneficial in the treatment of certain heart conditions and improving cardiac performance.

Upstream product

• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 883987-74-4 3-fluoro-5-nitrobenzyl alcohol 
• 1214344-25-8 1-(chloromethyl)-3-fluoro-5-nitrobenzene 
• 1289135-50-7 C₇H₆FNO 
• 873697-58-6 C₁₆H₂₂FN₃O₄ 
• 108160-01-6 C₂₂H₁₄FN₃O₂S 

Relevant academic research and scientific papers

Compounds, Compositions and Methods

Certain substituted urea derivatives modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Elemental fluorine. Part 21. (1) direct fluorination of benzaldehyde derivatives

Direct fluorination of a range of benzaldehyde derivatives gives mixtures of fluorobenzaldehyde and benzoyl fluoride products in ratios that depend upon the nature of the ring substituent Electron-withdrawing substituents give predominantly benzoyl fluoride derivatives, whereas electron-donating substituents lead to fluoroarene systems. Separation of ring-fluorinated products can be easily accomplished by esterification of the benzoyl fluoride side products. Scale-up of these processes to provide significant quantities of appropriate fluorobenzaldehyde systems has also been achieved using continuous flow techniques.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Compounds, compositions and methods

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.