883987-74-4

Basic information

• Product Name: (3-fluoro-5-nitrophenyl)Methanol
• Synonyms: (3-fluoro-5-nitrophenyl)Methanol
• CAS NO: 883987-74-4
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.1258432
• Mol File: 883987-74-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-fluoro-5-nitrophenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-fluoro-5-nitrophenyl)Methanol(883987-74-4)
• EPA Substance Registry System: (3-fluoro-5-nitrophenyl)Methanol(883987-74-4)

Safety Data

• Hazardous Substances Data: 883987-74-4(Hazardous Substances Data)

Usage

General Description

(3-fluoro-5-nitrophenyl)Methanol is a chemical compound consisting of a methanol molecule attached to a phenyl ring with a fluorine atom at the 3-position and a nitro group at the 5-position. (3-fluoro-5-nitrophenyl)Methanol is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also utilized in the production of dyes, pigments, and other fine chemicals. The fluoro and nitro functional groups in (3-fluoro-5-nitrophenyl)Methanol make it a versatile reagent for the introduction of these substituents into other organic molecules, allowing for the synthesis of a wide range of complex compounds. Additionally, it can be used as a precursor for the preparation of fluorinated and nitro-substituted organic materials for use in various industrial applications.

Upstream product

• 108159-96-2 3-fluoro-5-nitrobenz-aldehyde 
• 850807-07-7 ethyl 3-fluoro-5-nitrobenzoate 
• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 883987-72-2 methyl 3-fluoro-5-nitrobenzoate 

Downstream Products

• 1214344-25-8 1-(chloromethyl)-3-fluoro-5-nitrobenzene 
• 873697-58-6 C₁₆H₂₂FN₃O₄ 
• 883987-75-5 1-(bromomethyl)-3-fluoro-5-nitrobenzene 

Relevant articles and documents

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

(R)-3-(N,N-DIMETHYLAMINO)PYRROLIDINE DERIVATIVES

(R)-3-(N,N-Dimethyiamino)pyrrolidine derivatives of formula (I), wherein the meaning for Cy1 is as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.