883987-74-4

Usage

Uses

Used in Organic Synthesis:
(3-fluoro-5-nitrophenyl)Methanol is used as a building block in organic synthesis for the preparation of pharmaceuticals and agrochemicals. Its presence of fluoro and nitro functional groups allows for the creation of a diverse array of complex organic compounds with potential applications in medicine and agriculture.
Used in the Production of Dyes and Pigments:
(3-fluoro-5-nitrophenyl)Methanol is utilized as a precursor in the production of dyes and pigments, where its specific functional groups contribute to the color and stability of the final products.
Used in the Preparation of Fine Chemicals:
In the fine chemicals industry, (3-fluoro-5-nitrophenyl)Methanol serves as a versatile reagent for the synthesis of specialty chemicals that require the introduction of fluorine and nitro substituents, enhancing the properties of these chemicals for specific applications.
Used in Industrial Applications:
(3-fluoro-5-nitrophenyl)Methanol is also used as a precursor for the preparation of fluorinated and nitro-substituted organic materials, which are employed in a variety of industrial applications due to their unique chemical and physical properties.

Upstream product

• 108159-96-2 3-fluoro-5-nitrobenz-aldehyde 
• 850807-07-7 ethyl 3-fluoro-5-nitrobenzoate 
• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 883987-72-2 methyl 3-fluoro-5-nitrobenzoate 

Downstream Products

• 883987-75-5 1-(bromomethyl)-3-fluoro-5-nitrobenzene 
• 1214344-25-8 1-(chloromethyl)-3-fluoro-5-nitrobenzene 
• 873697-58-6 C₁₆H₂₂FN₃O₄ 

Relevant academic research and scientific papers

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I): wherein, A, C, D, X, and Y have any of the values defined in the specification, and salts thereof. The compounds are SIRT2 inhibitors and are useful for treating SIRT2 associated conditions.

(R)-3-(N,N-DIMETHYLAMINO)PYRROLIDINE DERIVATIVES

(R)-3-(N,N-Dimethyiamino)pyrrolidine derivatives of formula (I), wherein the meaning for Cy1 is as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, X1, R6, r and R7 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.