108183-41-1Relevant academic research and scientific papers
1-Aminovinylphosphonate Esters as Substrates for the Diels-Alder Reaction: First Synthetic and Theoretical Study
Jiménez-Andreu, M. Mercedes,Bueno-Morón, Jorge,Sayago, Francisco J.,Cativiela, Carlos,Tejero, Tomás,Merino, Pedro
, p. 1268 - 1272 (2019/01/24)
The Diels-Alder reaction of 1-aminovinylphosphonate esters has been studied for the first time as a suitable procedure leading to quaternary carbocyclic α-aminophosphonates. The reaction is influenced by steric effects at the phosphonate functionality (bulky groups hinder the reaction) and electronic effects at the amino group (electron-withdrawing substituents increase the reaction rate). The exo/endo ratio is constant, and no influence of the solvent is observed. The experimental results have been rationalized by DFT methods.
Diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
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, (2008/06/13)
A compound of the formula: STR1 wherein R1 --A-- is a group of the formula: STR2 in which R1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, and X is O or S, and R2 is hydrogen or lower alkyl, provided that when R1 is lower alkyl, then R1 --A-- is a group of the formula: STR3 in which R1 and X are each as defined above, and pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.
Synthese von 1-Aminophosphonsaeure ueber Acyliminophosphonsaeure-Ester
Schrader, Thomas,Kober, Reiner,Steglich, Wolfgang
, p. 372 - 375 (2007/10/02)
1-Acylaminomethylphosphonates 1 on reaction with N-bromosuccinimide yield 1-acylamino-1-bromomethylphosphonates 2, which on treatment with tertiary amines are converted into acyliminophosphonates 3.The latter react in situ with nucleophiles like enamines,
