20495-33-4Relevant academic research and scientific papers
A new way for potential aminophosphonic acids precursors
Cristau, Henri-Jean,Lambert, Jean-Marc,Sarris, Anne,Pirat, Jean-Luc
, p. 125 (2007/10/03)
New five membered-ring 3,3-dihydro-1,4,2-oxazaphospholenes 1, potential precursors of aminophosphonic acids, have been synthesized and characterized by 1H, 13C and 31P NMR.
Convenient Preparations of Diethyl phosphonates, 2-Azabutadienes, and Isoquinolines from a 1,2-Monoazabisylide Equivalent
Katritzky, Alan R.,Zhang, Guifen,Jiang, Jinlong
, p. 4556 - 4560 (2007/10/02)
Diethyl methyl>phosphonate (4), prepared in situ by treatment of 1-methyl>benzotriazole (betmip 6) with diethyl phosphite anion, is converted by treatment with butyllithium into the corresponding carbanion 5.Carbanion 5, the first example of a 1,2-monoazabisylide equivalent, provides a versatile synthetic method to introduce the C=NC=C structural unit, as illustrated by convenient preparations of 1,4-diaryl-2-azabutadienes, 1,1,4,4-tetraaryl-2-azabutadienes, diethyl phosphonates, and isoquinolines.
CONVERSION OF AMINO ACIDS AND DIPEPTIDES INTO THEIR PHOSPHONIC ANALOGS; Aminoalkylphosphonic acids and peptides II.
Oesapay, George,Szilagyi, Ildiko,Seres, Jenoe
, p. 2977 - 2984 (2007/10/02)
Acylamino carboxylic acids were degradated by the Hunsdiecker-reaction; the bromo-derivatives were reacted with NaPO(OC2H5)2.Aminophosphonic acids were obtained by acidic hydrolysis, and half-blocked derivatives by the selective removal of masking substituents.Two phosphonopeptides were also prepared by this route.
