108227-95-8

Upstream product

• 52329-60-9 (2-amino-1H-benzimidazol-5-yl)(phenyl)methanone 
• 75-36-5 acetyl chloride 
• 31431-39-7 mebendazole 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 57070-71-0 (3,4-diaminophenyl)phenylmethanone hydrochloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 75501-04-1 2-acetamido-5(6)-(α-hydroxy-α-phenylmethyl)benzimidazole 

Relevant academic research and scientific papers

Antiparasitic agents: Part XVII - Synthesis of 5-acyl-2-acylamino-1H-benzimidazoles and their macrofilaricidal and chemosterilizing activities

5-Acyl-2-acylamino-1H-benzimidazoles (3a-w) have been synthesized and evaluated for their macrofilaricidal and chemosterilizing activities in experimental animals.Compounds 3a,b,q exhibit high order of adulticidal activity against L. carinii (cotton rats) and A. viteae (Mastomys) infections while compounds 3b,o q show marked chemosterilizing effect on adult female filariids.

Studies in Antiparasitic Agents: Part 8 - Synthesis of 2-Substitutedamino-5(6)-benzoylbenzimidazoles as Structural Analogs of Mebendazole Metabolites

The synthesis of a series of 2-substitutedamino-5(6)-benzoylbenzimidazoles (6-22) has been carried out as the structural analogs of 2-amino-5(6)-benzoyl/α-hydroxy-α-phenylmethylbenzimidazoles (3, 4), the two metabolites of mebendazole.The compounds 6-22 have been tested for their anthelmintic activity against Ancylostoma ceylanicum, Nippostrongylus brasiliensis and Hymenolepis nana in rodents.Compounds 9, 11, 12, 13 and 14 exhibit 100percent elimination of A. ceylanicum worms from the animals at a single oral dose of 50-250 mg/kg.Some of the compounds also show activity against H. nana and N. brasiliensis.