108260-04-4

Basic information

• Product Name: cefalexin
• Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-
• CAS NO: 108260-04-4
• Molecular Formula: C₁₆H₁₇N₃O₄S
• Molecular Weight: 0
• Mol File: 108260-04-4.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cefalexin(CAS DataBase Reference)
• NIST Chemistry Reference: cefalexin(108260-04-4)
• EPA Substance Registry System: cefalexin(108260-04-4)

Safety Data

• Hazardous Substances Data: 108260-04-4(Hazardous Substances Data)

Upstream product

• 34959-72-3 (6R,7R,4'R)-7-(2',2'-dimethyl-3'-nitroso-5'-oxo-4'-phenylimidazolidin-1'-yl)-3-methylceph-3-em-4-carboxylate 
• 72059-35-9 7-aminodesacetoxy-cephalosporanic acid 
• 103-83-3 N,N'-dimethylbenzylamine 
• 105-45-3 acetoacetic acid methyl ester 
• 79-22-1 methyl chloroformate 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 40647-89-0 (R)-Amino-phenyl-acetyl chloride 
• 25705-52-6 (R)-phenylglycine hydrochloride 
• 700-63-0 (R)-phenylglycine amide 
• 934002-65-0 (D)-phenylglycine methyl ester methanesulphonate 
• 39754-01-3 cephalexin p-nitrobenzyl ester tosylate salt 
• 611-71-2 MANDELIC ACID 
• 51795-31-4 (6R,7R)-7-amino-3-methylenecepham-4-carboxylic acid 

Downstream Products

• 59310-01-9 (6R)-7t-((R)-2-formylamino-2-phenyl-acetylamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 34959-72-3 (6R,7R,4'R)-7-(2',2'-dimethyl-3'-nitroso-5'-oxo-4'-phenylimidazolidin-1'-yl)-3-methylceph-3-em-4-carboxylate 
• 67341-53-1 2-hydroxy-3-phenyl-6-methylpyrazine 
• 79750-46-2 (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 
• 875-74-1 (R)-phenylglycine 

Related news

A new biocompatible gentle aqueous biphasic system in cefalexin (cas 108260-04-4) partitioning containing nonionic Tween 20 surfactant and three organic/inorganic different salts09/01/2019

In this work, nonionic biocompatible Tween 20 based aqueous two-phase systems (ATPSs) were studied. These systems provide a gentle media with low interfacial tension for extraction of biomolecules. In accordance with the results, the top phase tends to be surfactant-rich and the bottom phase ten...detailed

The long-term impact of cefalexin (cas 108260-04-4) on organic substrate degradation and microbial community structure in EGSB system08/31/2019

In order to investigate long-term effect of cefalexin (CFX) on the performance of expanded granular sludge bed (EGSB) system and microbial community structure, two 1.47 L EGSB reactors E1 and E2 were designed and run for 224 days treating with synthetic antibiotic wastewater. For the purpose of ...detailed

Biodegradability enhancement of wastewater containing cefalexin (cas 108260-04-4) by means of the electro-Fenton oxidation process08/29/2019

The comparative degradation behavior of cefalexin (CLX) using advanced oxidation processes (AOPs) with the aim of improving CLX biodegradability was studied. Among the AOPs used, RuO2/Ti anodic oxidation (AO), AO in the presence of electro-generated H2O2 (AO-H2O2), and the electro-Fenton (EF) pr...detailed

Effect of surface properties of activated carbon fiber cathode on mineralization of antibiotic cefalexin (cas 108260-04-4) by electro-Fenton and photoelectro-Fenton treatments: Mineralization, kinetics and oxidation products08/28/2019

Solutions of 200 mg L−1 cefalexin (CLX), an antibiotic with high usage frequency and biodegradation resistance, have been comparatively degraded by electro-Fenton (EF) and photoelectro-Fenton (PEF) processes using two kinds of activated carbon fiber (ACF) cathodes with different physical propert...detailed

Inclusion of cefalexin (cas 108260-04-4) in SBA-15 mesoporus material and release property08/27/2019

SBA-15 (Santa Barbara Amorphous-15) is a high ordered mesoporous material. It has the advantages of a non-toxic property, good hydrothermal stability and thermal stability, etc. Inside inner surface a lot of silanols exist. Pore diameter size is uniform and pore size distribution is narrow. This...detailed

Susceptibility of coagulase-negative staphylococci to a kanamycin and cefalexin (cas 108260-04-4) combination08/26/2019

A combination of kanamycin and cefalexin was licensed in Europe in 2008 to treat bovine clinical mastitis. Preliminary broth and disk clinical breakpoints for this antibiotic combination have been proposed for Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, and Escherich...detailed

Oxidation of cefalexin (cas 108260-04-4) by thermally activated persulfate: Kinetics, products, and antibacterial activity change08/25/2019

While the widely used β-lactam antibiotics, such as cephalosporins, are known to be susceptible to oxidation by sulfate radical (SO4−), comprehensive study about SO4−-induced oxidation of cephalosporins is still limited, such as the impact of water matrices, and the structure and antibacterial ...detailed

Characterization of cefalexin (cas 108260-04-4) degradation capabilities of two Pseudomonas strains isolated from activated sludge08/24/2019

Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of ...detailed

Hydrophilic-interaction planar chromatography in ultra-sensitive determination of α-aminocephalosporin antibiotics. Application to analysis of cefalexin (cas 108260-04-4) in goat milk samples using modified QuEChERS extraction technique08/23/2019

A highly sensitive, selective and precise HPTLC method coupled with fluorescence detection was developed and validated for the determination of α-aminocephalosporin antibiotics; namely cefalexin, cefadroxil and cefradine in their standard solutions. The applicability of the developed methodolog...detailed

Relevant articles and documents

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Preparation method of cefalexin

The invention belongs to the field of medicine synthesis, in particular to an improved method of a beta-lactam antibiotic cefalexin synthesis process. According to the method, 7-ADCA is used as a rawmaterial and is protected by carboxyl silane; after activation with alpha-aminophenylacetic acid hydrochloride and trifluoroacetic acid succinimide, condensation reaction is carried out; cefalexin isobtained through hydrolysis after-treatment, the proper pH value is controlled through hydrochloric acid after organic solvent and alkali adjustment treatment, and cefalexin crystals with extremely high purity are obtained. The method has the advantages of being easy and convenient to operate, mild in reaction condition, not prone to causing side reaction and capable of effectively removing impurities and preparing high-purity cefalexin.

MANUFACTURING METHOD AND APPARATUS OF ULTRAFINE PARTICLES HAVING UNIFORM PARTICLE SIZE DISTRIBUTION

The present invention relates to a novel technology for forming fine particles with a size of 0.02?3 microns from a solid that can be dissolved in a liquid solvent and is not decomposed by heat. The particle preparation technology according to the present invention may be applicable to the fields of food, cosmetics, biopolymer, polymer compositions, and pharmaceuticals.

Synthesis of cephalosporin-type antibiotics by coupling of their β-lactam nucleus and racemic amino acid side chains using a clathration-induced asymmetric transformation

The cephalosporin-type antibiotics Cephalexin, Cephradine and Cefadroxil have been prepared by coupling of their β-lactam nucleus and racemic amino acid side chain precursors. The initially obtained mixture of cephalosporin epimers is subjected to a clathration-induced asymmetric transformation which results in the epimerization of the epi-cephalosporin into the cephalosporin with the correct diastereomeric configuration.