1082674-24-5

Basic information

• Product Name: 6-Bromo-1-isoquinolinecarbonitrile
• Synonyms: 6-Bromo-1-isoquinolinecarbonitrile
• CAS NO: 1082674-24-5
• Molecular Formula: C₁₀H₅BrN₂
• Molecular Weight: 233.0641
• Mol File: 1082674-24-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 152℃
• Boiling Point: 403.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.66±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.02±0.38(Predicted)
• CAS DataBase Reference: 6-Bromo-1-isoquinolinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1-isoquinolinecarbonitrile(1082674-24-5)
• EPA Substance Registry System: 6-Bromo-1-isoquinolinecarbonitrile(1082674-24-5)

Safety Data

• Hazardous Substances Data: 1082674-24-5(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-isoquinolinecarbonitrile is an organic chemical compound with the molecular formula C10H5BrN2. It is a pale yellow solid that is primarily used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. It is a versatile intermediate in organic synthesis and has found applications in the development of new drugs and pesticides. Its unique structure and reactivity make it a valuable tool for medicinal chemistry research and drug discovery. Additionally, its properties make it useful in the development of new materials and the synthesis of complex organic molecules.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 223671-16-7 6-bromoisoquinoline nitrogen oxide 
• 34784-05-9 6-bromo-isoquinoline 

Downstream Products

• 1612755-71-1 6-[(4R)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile 
• 1612755-72-2 6-[(4S)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile 
• 1612755-63-1 6-[(3S)-3-(4-chlorophenyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]isoquinoline-1-carbonitrile 
• 23687-26-5 6-isoquinolinamine 

Relevant articles and documents

CARBONITRILE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention relates to a compound of Formula 1, 2 or 3: I II III wherein A is N or -CR0--, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1- C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2)q--, --(CHRs)q--, or -(CRsRt)q- -, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, for the treatment of certain diseases, particularly those affected or mediated by the androgen receptor; to compbinations comprising such compounds with a second pharmaceutically active ingredient; to compositions containing such combinations; and to such combinations for the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.