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108384-35-6

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108384-35-6 Usage

General Description

1-Cyclopentene-1-carboxylic acid, 3-oxo-, methyl ester (9CI) is a chemical compound with the molecular formula C8H10O3. It is a methyl ester derivative of 1-cyclopentene-1-carboxylic acid, which is a cyclic carboxylic acid with a double bond in the five-membered ring. 1-Cyclopentene-1-carboxylicacid,3-oxo-,methylester(9CI) is commonly used in the synthesis of various organic compounds and pharmaceuticals. It has the potential to be used as a precursor in the production of other chemicals due to its reactivity and versatile chemical properties. However, it is important to handle this compound with caution, as it can be hazardous if not used and handled properly. Overall, 1-cyclopentene-1-carboxylic acid, 3-oxo-, methyl ester (9CI) is an important building block in organic chemistry with various potential applications.

Check Digit Verification of cas no

The CAS Registry Mumber 108384-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,8 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 108384-35:
(8*1)+(7*0)+(6*8)+(5*3)+(4*8)+(3*4)+(2*3)+(1*5)=126
126 % 10 = 6
So 108384-35-6 is a valid CAS Registry Number.

108384-35-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 3-oxocyclopentene-1-carboxylate

1.2 Other means of identification

Product number -
Other names 3-methoxycarbonyl-2-cyclopentenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108384-35-6 SDS

108384-35-6Relevant articles and documents

Asymmetric Synthesis of N-Substituted γ-Amino Esters and γ-Lactams Containing α,γ-Stereogenic Centers via a Stereoselective Enzymatic Cascade

Li, Ming,Cui, Yunfeng,Xu, Zefei,Chen, Xi,Feng, Jinhui,Wang, Min,Yao, Peiyuan,Wu, Qiaqing,Zhu, Dunming

supporting information, p. 372 - 379 (2021/10/25)

γ-Amino esters and γ-lactams containing α,γ-stereogenic centers are widely used as chiral intermediates in various bioactive compounds, while their efficient synthesis remains a challenge. Herein, an enzymatic cascade reaction involving an ene reductase (

Biocatalytic access to nonracemic γ-oxo esters: Via stereoselective reduction using ene-reductases

Turrini, Nikolaus G.,Cioc, Rǎzvan C.,Van Der Niet, Daan J. H.,Ruijter, Eelco,Orru, Romano V. A.,Hall, Mélanie,Faber, Kurt

supporting information, p. 511 - 518 (2017/08/14)

The asymmetric bioreduction of α,β-unsaturated γ-keto esters using ene-reductases from the Old Yellow Enzyme family proceeds with excellent stereoselectivity and high conversion levels, covering a broad range of acyclic and cyclic derivatives. Various strategies were employed to provide access to both enantiomers, which are versatile precursors of bioactive molecules. The regioselectivity of hydride addition on di-activated alkenes was elucidated by isotopic labeling experiments and showed strong preference for the keto moiety as activating/binding group as opposed to the ester. Finally, chemoenzymatic synthesis of (R)-2-(2-oxocyclohexyl)acetic acid was achieved in high ee on a preparative scale combining enzymatic reduction followed by ester hydrogenolysis.

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

Krall, Jacob,Jensen, Claus Hatt,Bavo, Francesco,Falk-Petersen, Christina Birkedahl,Haugaard, Anne St?hr,Vogensen, Stine Byskov,Tian, Yongsong,Nittegaard-Nielsen, Mia,Sigurdardóttir, Sara Bj?rk,Kehler, Jan,Kongstad, Kenneth Thermann,Gloriam, David E.,Clausen, Rasmus Pr?torius,Harps?e, Kasper,Wellendorph, Petrine,Fr?lund, Bente

, p. 9022 - 9039 (2017/11/14)

γ-Hydroxybutyric acid (GHB) is a neuroactive substance with specific high-affinity binding sites. To facilitate target identification and ligand optimization, we herein report a comprehensive structure-affinity relationship study for novel ligands targeting these binding sites. A molecular hybridization strategy was used based on the conformationally restricted 3-hydroxycyclopent-1-enecarboxylic acid (HOCPCA) and the linear GHB analog trans-4-hydroxycrotonic acid (T-HCA). In general, all structural modifications performed on HOCPCA led to reduced affinity. In contrast, introduction of diaromatic substituents into the 4-position of T-HCA led to high-affinity analogs (medium nanomolar Ki) for the GHB high-affinity binding sites as the most high-affinity analogs reported to date. The SAR data formed the basis for a three-dimensional pharmacophore model for GHB ligands, which identified molecular features important for high-affinity binding, with high predictive validity. These findings will be valuable in the further processes of both target characterization and ligand identification for the high-affinity GHB binding sites.

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