132076-27-8

Basic information

• Product Name: Cyclopentanecarboxylic acid, 3-oxo-, methyl ester, (R)- (9CI)
• Synonyms: Cyclopentanecarboxylic acid, 3-oxo-, methyl ester, (R)- (9CI);methyl (1R)-3-oxocyclopentane-1-carboxylate;(R)-Methyl 3-oxocyclopentanecarboxylate;(R)-3-Oxo-cyclopentanecarboxylic acid methyl ester
• CAS NO: 132076-27-8
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.1525
• Product Categories: CARBOXYLICESTER
• Mol File: 132076-27-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 209.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.157±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Cyclopentanecarboxylic acid, 3-oxo-, methyl ester, (R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 3-oxo-, methyl ester, (R)- (9CI)(132076-27-8)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 3-oxo-, methyl ester, (R)- (9CI)(132076-27-8)

Safety Data

• Hazardous Substances Data: 132076-27-8(Hazardous Substances Data)

Usage

Description

(R)-3-Oxo-cyclopentanecarboxylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

(R)-3-Oxo-cyclopentanecarboxylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.[Cayman Chemical]

Upstream product

• 162086-59-1 3-hydroxy-cyclopentene-1-carboxylic acid methyl ester 
• 25662-28-6 1-(carboxymethoxy)cyclopentadiene 
• 108384-35-6 methyl 3-oxocyclopent-1-enecarboxylate 
• 98-78-2 3-Oxo-cyclopentanecarboxylic acid 
• 67-56-1 methanol 
• 13012-38-9 (1R)-3-oxocyclopentane-1-carboxylic acid 

Downstream Products

• 1292307-06-2 methyl (1R,3R)-3-hydroxycyclopentane-1-carboxylate 
• 174292-59-2 (1R,3S)-methyl 3-hydroxycyclopentanecarboxylate 

Relevant articles and documents

Asymmetric Synthesis of N-Substituted γ-Amino Esters and γ-Lactams Containing α,γ-Stereogenic Centers via a Stereoselective Enzymatic Cascade

γ-Amino esters and γ-lactams containing α,γ-stereogenic centers are widely used as chiral intermediates in various bioactive compounds, while their efficient synthesis remains a challenge. Herein, an enzymatic cascade reaction involving an ene reductase (

Biocatalytic synthesis of chiral cyclic γ-oxoesters by sequential C-H hydroxylation, alcohol oxidation and alkene reduction

A three-step biocatalytic procedure is described for the conversion of methyl and ethyl cyclopentene- and cyclohexenecarboxylates into both the enantiomers of the corresponding chiral 3-oxoesters, which are useful building blocks for the synthesis of active pharmaceutical ingredients. The allylic hydroxylation of the starting cycloalkenecarboxylates is carried out by using R. oryzae resting cells entrapped in alginate beads, in acetate buffer solution at 25 °C. The oxidation of the intermediate allylic alcohols to unsaturated ketones, performed by the laccase/TEMPO system, and the ene-reductase mediated hydrogenation of the alkene bond were carried out in the same reaction vessel in a sequential mode at 30 °C. Being entirely biocatalytic, our multistep procedure provides considerable advantages in terms of selectivity and environmental impact over reported chemical methods.

ADENYLYL CYCLASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF

The present invention relates to novel adenine based inhibitors of adenylyl cyclase of the formula: wherein X, L, R1, R2, R5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.