1084-95-3Relevant academic research and scientific papers
Cobalt(II)-Catalyzed Csp2-H Alkynylation/Annulation with Terminal Alkynes: Selective Access to 3-Methyleneisoindolin-1-one
Zhang, Lin-Bao,Hao, Xin-Qi,Liu, Zhan-Jiang,Zheng, Xin-Xiang,Zhang, Shou-Kun,Niu, Jun-Long,Song, Mao-Ping
, p. 10012 - 10015 (2015)
A highly efficient cobalt(II)-catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O-bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approa
An efficient mesoporous carbon nitride (g-C3N4) functionalized Pd catalyst for carbon-carbon bond formation reactions
Elavarasan,Baskar,Senthil,Bhanja, Piyali,Bhaumik,Selvam,Sasidharan
, p. 49376 - 49386 (2016)
Metal nanoparticles in pristine form without any stabilizing agents and free from agglomeration are very critical for their function and diverse catalytic applications. With the goal to accomplish a molecularly defined Pd-based heterogeneous C-C bond form
Use of Imidazo[1,5-a]pyridin-3-ylidene as a Platform for Metal-Imidazole Cooperative Catalysis: Silver-Catalyzed Cyclization of Alkyne-Tethered Carboxylic Acids
Rawat, Vishal Kumar,Higashida, Kosuke,Sawamura, Masaya
supporting information, p. 1631 - 1637 (2021/02/03)
Silver complexes with 5-(4-(tert-butyl)-1H-imidazol-1-yl)-imidazo[1,5-a]pyridin-3-ylidene ligands were synthesized as metal-imidazole acid-base cooperative catalysts. Single crystal XRD analysis revealed that the silver atom was located in the vicinity of
Iridium-Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones
Huang, Yi,Zhang, Xianghe,Dong, Xiu-Qin,Zhang, Xumu
supporting information, p. 782 - 788 (2020/01/08)
The iridium-catalyzed cycloisomerization of various alkynoic acids was successfully developed, and a series of five-, six-, and especially seven-membered unsaturated lactones were constructed with moderate yields and excellent regioselectivities (up to 68
Fe(III)-Catalyzed, Cyclizative Coupling between 2-Alkynylbenzoates and Carbinols: Rapid Generation of Polycyclic Isocoumarins and Phthalides and Mechanistic Study
Gandhi, Soniya,Baire, Beeraiah
, p. 2651 - 2657 (2020/05/25)
FeCl3 catalyzed, highly regioselective cyclizative coupling of internal alkynes with alcohols has been reported for the rapid synthesis of structurally divergent, complex isocoumarins and phthalides respectively in intermolecular and intramolecular fashion. This strategy exhibited very high substrate scope and efficiency and proceeds through the simultaneous formation of C?O and C?C bonds. Observations from a series of control experiments supported a) the mechanism as Lewis acid catalyzed dual activation of ester and alcohol, b) the role of carbocation for the enhanced rates of cyclization, i. e., activation of alkyne by carbocation, and c) no role of HCl in the reported cascade process. (Figure presented.).
Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity
Qiao, Jin,Jia, Xiuwen,Li, Pinyi,Liu, Xiaoyan,Zhao, Jingwei,Zhou, Yu,Wang, Jiang,Liu, Hong,Zhao, Fei
, (2019/02/07)
1,3-unsubstituted 2-(1H-indol-2-yl)ethanamines were employed for the first time to react with alkynoic acids (AAs) to achieve gold-catalyzed highly selective cascade reactions to furnish novel indole-fused skeletons. Furthermore, with this powerful gold catalytic system, a library of indole/pyrrole/thiophene/benzene/naphthalene/pyridine-based nitrogen-containing heterocyclic compounds (NCHCs) with scaffold diversity and molecular complexity was constructed rapidly using various amine nucleophiles (ANs) and diverse AAs as the building blocks. This general protocol features excellent selectivity, extraordinarily broad substrate scope, readily available inputs, good to high yields, high bond-forming efficiency, and step economy, thus providing a facile and efficient access to a variety of valuable nitrogen-containing heterocycles.
Preparation method of 3-hydroxy-2,3-dihydroisoquinoline-1,4-dione compound
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Paragraph 0045; 0046; 0060; 0061, (2019/08/01)
The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of a 3-hydroxy-2,3-dihydroisoquinoline-1,4-dione compound. In the preparation methodprovided by the invention, N-alkoxy-2-alkynyl benzamide
Green preparation method of 3-hydroxy isoindole-1-one compounds
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Paragraph 0037; 0042; 0045, (2020/01/03)
The invention discloses a green preparation method of 3-hydroxy isoindole-1-one compounds, and belongs to the technical field of organic synthesis. The method comprises the following steps: adopting 2-alkynyl benzamide as a reaction substrate, adding a br
Divergent Syntheses of (Z)-3-Alkylideneisobenzofuran-1(3 H)-ones and 1 H-Isochromen-1-ones by Copper-Catalyzed Cycloisomerization of 2-Alkynylbenzoic Acids in Ionic Liquids
Mancuso, Raffaella,Pomelli, Christian S.,Chiappetta, Piera,Gioia, Katia F.,Maner, Asif,Marino, Nadia,Veltri, Lucia,Chiappe, Cinzia,Gabriele, Bartolo
, p. 6673 - 6680 (2018/06/01)
The cycloisomerization of readily available 2-alkynylbenzoic acids 1 in ionic liquids (ILs) as recyclable reaction media has been studied under the catalytic action of CuCl2. With substrates bearing an aryl group on the triple bond, a mixture o
Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes
Lv, Jiahang,Zhao, Binlin,Liu, Li,Han, Ying,Yuan, Yu,Shi, Zhuangzhi
supporting information, p. 4054 - 4059 (2018/09/25)
We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of usefu
