108432-90-2Relevant articles and documents
Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents
Bavikar, Sudhir N.,Salunke, Deepak B.,Hazra, Braja G.,Pore, Vandana S.,Dodd, Robert H.,Thierry, Josiane,Shirazi, Fazal,Deshpande, Mukund V.,Kadreppa, Sreenath,Chattopadhyay, Samit
, p. 5512 - 5517 (2008)
Tetrapeptides derived from glycine and β-alanine were hooked at the C-3β position of the modified cholic acid to realize novel linear tetrapeptide-linked cholic acid derivatives. All the synthesized compounds were tested against a wide variety of microorganisms (Gram-negative bacteria, Gram-positive bacteria and fungi) and their cytotoxicity was evaluated against human embryonic kidney (HEK293) and human mammary adenocarcinoma (MCF-7) cell lines. While relatively inactive by themselves, these compounds interact synergistically with antibiotics such as fluconazole and erythromycin to inhibit growth of fungi and bacteria, respectively, at 1-24 μg/mL. The synergistic effect shown by our novel compounds is due to their inherent amphiphilicity. The fractional inhibitory concentrations reported are comparable to those reported for Polymyxin B derivatives.
Conformations in the Solid State and Solubility Properties of Protected Homooligopeptides of Glycine and β-Alanine
Narita, Mitsuaki,Doi, Masamitsu,Kudo, Koji,Terauchi, Yusuke
, p. 3553 - 3558 (2007/10/02)
IR spectroscopic conformational analyses of Boc-Glyn-OBzl (n=3-7) and Boc-(β-Ala)n-OBzl (n=3-8) were performed in the solid state, suggesting the occurrence of the β-sheet structure in the higher oligomers (n=5-8).Solubility data ind
