108583-50-2Relevant academic research and scientific papers
Palladium-catalyzed C-H activation of simple arenes and cascade reaction with nitriles: access to 2,4,5-trisubstituted oxazoles
Dai, Ling,Yu, Shuling,Shao, Yinlin,Li, Renhao,Chen, Zhongyan,Lv, Ningning,Chen, Jiuxi
supporting information, p. 1376 - 1379 (2021/02/22)
An efficient and straightforward protocol for the assembly of the pharmaceutically and biologically valuable oxazole skeleton is achieved for the first time from readily available simple arenes and functionalized aliphatic nitriles. This transformation in
Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles
Dai, Ling,Yu, Shuling,Lv, Ningning,Ye, Xuanzeng,Shao, Yinlin,Chen, Zhongyan,Chen, Jiuxi
supporting information, p. 5664 - 5668 (2021/08/01)
We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids a
Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins
Chen, Jiuxi,Chen, Zhongyan,Dai, Ling,Shao, Yinlin,Xiong, Wenzhang,Xu, Tong,Yu, Shuling
supporting information, (2020/04/15)
A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl
Synthesis of 2,4,5-Trisubstituted Oxazoles via Pd-Catalyzed C-H Addition to Nitriles/Cyclization Sequences
Zhang, Di,Song, Hao,Cheng, Na,Liao, Wei-Wei
supporting information, p. 2745 - 2749 (2019/04/30)
A practical and flexible intermolecular protocol for the diverse synthesis of trisubstituted oxazole derivatives via a Pd-catalyzed direct C-H addition of electronic-rich heteroarenes to O-acyl cyanohydrins bearing an α-hydrogen/cyclization sequence is described. A wide range of trisubstituted oxazoles can be prepared from readily available starting materials in good to high yields with high efficiency under redox neutral reaction conditions.
Cyanobenzoylation and hydrocyanation of aldehydes with benzoyl cyanide using no catalyst
Watahiki, Tsutomu,Ohba, Sayoko,Oriyama, Takeshi
, p. 2679 - 2681 (2007/10/03)
(Matrix presented) In the presence of MS 4A in DMSO, cyanobenzoylation of various aldehydes with benzoyl cyanide proceeded very smoothly to give the corresponding cyanohydrin benzoates in high to excellent yields without an acid or a base. On the other hand, reaction of aldehydes with BzCN in DMSO-H2O also occurred readily to afford the corresponding free cyanohydrins exclusively.
A convenient and improved method for the preparation of cyanohydrin esters from acyl cyanides and aldehydes
Okimoto, Mitsuhiro,Chiba, Toshiro
, p. 1188 - 1190 (2007/10/03)
Various kinds of cyanohydrin esters can be obtained in good to excellent yields from aldehydes by treatment with acyl cyanides in a heterogeneous mixture of aqueous potassium carbonate and acetonitrile.
A Simple One-Pot Synthesis of Silylated and Acylated Cyanohydrins
Yoneda, Ryuji,Santo, Kazunori,Harusawa, Shinya,Kurihara, Takushi
, p. 1054 - 1055 (2007/10/02)
Reaction of variety of aldehydes and ketones with chlorotrimethylsilane and acyl chlorides in the presence of lithium cyanide to give trimethylsilylcyanohydrins and acylcyanohydrins is described.
